Actively Recruiting
The Effects of Social Isolation and Social Interaction on the Risk of Dementia Progression and Brain Function in Subjective Cognitive Decline (SCD)
Led by The First Affiliated Hospital with Nanjing Medical University · Updated on 2024-03-28
209
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating how social isolation and social interaction affect the risk of dementia progression and brain function in people with Subjective Cognitive Decline (SCD). The study aims to explore the link between social isolation, loneliness, and the development of Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD), as well as to understand how genetic factors like APOEb54 allele influence this progression. The research also focuses on creating a model to predict cognitive decline from SCD to MCI and AD and to confirm if social interaction protects cognitive function in SCD patients. The study involves observing groups of SCD participants with different levels of social isolation, measured by the Lubben Social Network Scale (LSNS-6). Participants are categorized as socially isolated (LSNS-6 612) or non-socially isolated (LSNS-6 >12). Researchers will collect and analyze data on brain network connectivity, walking ability, and genetic markers like APOE genotyping. This observational study includes cohort follow-up over 3 to 5 years and uses various cognitive tests and imaging techniques. Participants will be assessed through cognitive tests such as MoCA, AVLT-H, and fMRI scans at enrollment and at 3- and 5-year intervals. Researchers will monitor the incidence of MCI and AD over about one year and evaluate changes in brain function and social interaction measures. The study includes questionnaires on loneliness, depression, and sleep quality, as well as dual-task walking tests to understand cognitive and physical abilities. Overall participation could last several years with regular assessments to track cognitive decline and brain health.
CONDITIONS
Brief Title
The Effects of Social Isolation and Social Interaction on the Risk of Dementia Progression and Brain Function in SCD (Subjective Cognitive Decline, SCD)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Self-perceived continuous cognitive decline compared with previous normal state, not related to acute events
- Normal results on standard cognitive tests after adjusting for age, gender, and education, or do not meet criteria for mild cognitive impairment
- Able to provide informed consent independently
- Aged between 45 and 85 years
You will not qualify if you...
- Under 45 years or over 85 years of age
- Diagnosis of vascular dementia or other central nervous system diseases
- Hachinski Ischemic Scale score greater than 4
- Unable to complete neuropsychological tests due to conditions like blindness, deafness, or severe language impairment
- Drug abuse or alcohol dependency within the last 6 months
- Currently enrolled in other cognition studies
- Severe diabetes, cardiovascular, cerebrovascular, liver, kidney diseases, or psychiatric disorders
- Contraindications to imaging such as claustrophobia, metallic implants, or electronic devices like pacemakers
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - At enrollment
Participants undergo baseline assessments including APOE genotyping and brain imaging to evaluate cognitive and brain function.
1 visit (in-person)
Duration - Approximately 1 year
Participants are followed over an average of 1 year with repeated cognitive, behavioral, and brain function assessments to monitor the progression of cognitive decline.
Follow-up visits at 3 and 5 years for imaging and biomarker assessments
Trial Site Locations
Total: 1 location
1
The First Affiliated Hospital of Nanjing Medical University
Nanjing, China, Jiangsu, China, 210000
Actively Recruiting
Research Team
Z
Zhu Yi
S
Shi Chunxu
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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