Actively Recruiting
Effects of the Stimulation Site of Trans-spinal Magnetic Stimulation Combined With Transcranial Magnetic Stimulation on Functional Mobility in Individuals With Parkinson's Disease
Led by Universidade Federal de Pernambuco · Updated on 2026-03-23
30
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effects of two different trans-spinal magnetic stimulation (tsMS) sites, cervical versus thoracic, combined with repetitive transcranial magnetic stimulation (rTMS) on functional mobility in people with Parkinson's disease (PD). This randomized clinical trial aims to find which tsMS application site best improves mobility and motor outcomes, potentially helping to optimize and standardize tsMS protocols as an additional therapy for PD. Participants diagnosed with PD will be randomly assigned to one of two groups: one receiving rTMS over the primary motor cortex followed by cervical tsMS, and the other receiving rTMS followed by thoracic tsMS. Each participant will undergo 10 treatment sessions following these combined neuromodulation protocols. Throughout the study, participants will be assessed at baseline, at the end of the 10-day intervention, and at 15 and 30 days after treatment. Researchers will measure functional mobility using the Timed Up and Go Test, balance, motor function, gait speed, freezing of gait, lower limb strength, quality of life, global perceived improvement, and monitor any adverse events during the intervention period. The study is sponsored by Universidade Federal de Pernambuco and is expected to conclude by December 2026.
CONDITIONS
Brief Title
Effects of the Stimulation Site of tsMS With TMS on Functional Mobility in Individuals With Parkinson's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical diagnosis of Parkinson's disease confirmed by a neurologist
- Stable dopaminergic pharmacological treatment for at least three months
- Age 40 years or older
- Disease stage between 2.5 and 3 on the modified Hoehn and Yahr scale
- Gait impairment with at least one freezing of gait episode per week
You will not qualify if you...
- Other neurological disorders, orthostatic hypotension, vestibular, musculoskeletal, or visual impairments affecting assessments
- Osteomuscular conditions affecting lower limbs that interfere with mobility and function
- Montreal Cognitive Assessment (MoCA) score below 21 points
- Prior surgical procedures for Parkinson's disease
- Contraindications to magnetic stimulation, including history of seizures or metallic implants in neck or spine
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 10 days
Participants receive combined neuromodulation using repetitive transcranial magnetic stimulation (rTMS) applied over the primary motor cortex followed by trans-spinal magnetic stimulation (tsMS) at either the cervical or thoracic level.
Daily visits for 10 days
Duration - 20 days
Participants are monitored to assess functional mobility and other outcomes after the intervention ends.
2 visits at 15 and 30 days post-intervention
Trial Site Locations
Total: 1 location
1
Universidade Federal de Pernambuco
Recife, Pernambuco, Brazil
Actively Recruiting
Research Team
A
Ana Cecília Ribeiro Nascimento, Msc. student
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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