Comparing Cervical and Thoracic Trans-spinal Magnetic Stimulation Combined with Transcranial Magnetic Stimulation to Improve Mobility in Parkinsons Disease

What this Trial Is About

Researchers are evaluating the effects of two different trans-spinal magnetic stimulation tsMS sites, cervical versus thoracic, combined with repetitive transcranial magnetic stimulation rTMS on functional mobility in people with Parkinsons disease PD. This randomized clinical trial aims to find which tsMS application site best improves mobility and motor outcomes, potentially helping to optimize and standardize tsMS protocols as an additional therapy for PD. Participants diagnosed with PD will be randomly assigned to one of two groups one receiving rTMS over the primary motor cortex followed by cervical tsMS, and the other receiving rTMS followed by thoracic tsMS. Each participant will undergo 10 treatment sessions following these combined neuromodulation protocols. Throughout the study, participants will be assessed at baseline, at the end of the 10-day intervention, and at 15 and 30 days after treatment. Researchers will measure functional mobility using the Timed Up and Go Test, balance, motor function, gait speed, freezing of gait, lower limb strength, quality of life, global perceived improvement, and monitor any adverse events during the intervention period. The study is sponsored by Universidade Federal de Pernambuco and is expected to conclude by December 2026.

Effects of the Stimulation Site of tsMS With TMS on Functional Mobility in Individuals With Parkinson's Disease