Effects of Sufentanil on the Intraoperative Hemodynamic Parameters in Patients Undergoing Extracranial-intracranial Bypass Surgery: a Prospective Randomized Controlled Trial

What this Trial Is About

Researchers are conducting a randomized, controlled trial to study the effects of two different pain-relief drugs, sufentanil and remifentanil, during extracranial-intracranial bypass surgery. The study aims to compare how these drugs influence intraoperative blood pressure and heart rate during surgery. It involves adult patients undergoing this specific type of brain blood vessel surgery. Participants will be randomly assigned to one of two groups. One group receives sufentanil with an induction dose of 0.3 ng/ml and maintenance doses ranging from 0.05 to 0.5 ng/ml, while the other group receives remifentanil with an induction dose of 3 ng/ml and maintenance doses from 0.5 to 5 ng/ml. Both drugs are given during general anesthesia throughout the surgery. During the surgery, researchers will monitor blood pressure changes including episodes of low blood pressure, heart rate issues like bradycardia and tachycardia, and the need for medications to support heart function. The study tracks maximum and minimum systolic blood pressure during the operation. The entire process is overseen by Seoul National University Hospital and aims to enroll adult patients starting from age 19.

Effects of Sufentanil on the Intraoperative Hemodynamics