Actively Recruiting
Effects of Targeted Temporal Interference Stimulation of Cerebellar Nuclei on Tremor and Gait Disturbance in Parkinson's Disease Patients
Led by YangPan · Updated on 2026-03-23
50
Participants Needed
1
Research Sites
41 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to explore the effects of cerebellar nuclei TIS stimulation on improving tremor and gait disorders in PD patients. Through randomized double-blind grouping, the differences in efficacy between TIS intervention and sham stimulation intervention for tremor and gait disorders in PD patients will be compared.
CONDITIONS
Official Title
Effects of Targeted Temporal Interference Stimulation of Cerebellar Nuclei on Tremor and Gait Disturbance in Parkinson's Disease Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 50 years or older
- Confirmed diagnosis of idiopathic Parkinson's disease with tremor and gait disturbance
- Parkinson's disease duration of 2 years or more with stable condition
- Stable medication dose for at least 4 weeks before the study
- Positive response to Levodopa therapy
- Able to walk independently for at least 5 minutes and complete gait testing
- Signed informed consent and willingness to participate
You will not qualify if you...
- History or diagnosis of severe mental disorders like depression, anxiety, schizophrenia, or bipolar disorder
- Neurological conditions such as increased intracranial pressure, brain lesions, stroke, TIA within 2 years, cerebral aneurysm, dementia, or multiple sclerosis
- Severe cognitive impairment (Mini-Mental State Examination score below 22) or inability to complete questionnaires independently
- Inability to read or understand Chinese
- Use of other neuromodulatory treatments within the past 3 months
- Musculoskeletal or orthopedic issues greatly affecting gait or balance
- Presence of metal implants like deep brain stimulators or pacemakers, or contraindications for MRI/TIS
- Current use of medications affecting dopamine levels (e.g., antipsychotics)
- Severe cardiovascular disease or other unstable medical conditions that prevent physical exertion or study participation
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Zhongnan hospital
Wuhan, Hubei, China, 430000
Actively Recruiting
Research Team
Y
Yang Pan
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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