Study on Dexmedetomidine with Ear Nerve Stimulation to Prevent Nausea and Vomiting After Laparoscopic Surgery in Women

What this Trial Is About

This research aims to explore the effects and possible mechanisms of combining dexmedetomidine with transcutaneous auricular vagus nerve stimulation taVNS on reducing postoperative nausea and vomiting in female patients undergoing laparoscopic surgery. The study recruits women aged 18 to 65 who are scheduled for elective laparoscopic surgery under general anesthesia and meet specific health criteria. Participants are randomly assigned to one of two groups the taVNS group receives stimulation via a device placed on the left ear starting 30 minutes before anesthesia induction and continuing until the surgery ends, combined with intravenous dexmedetomidine infusion. The control group receives a sham stimulation device that does not deliver actual stimulation but follows the same schedule, also combined with dexmedetomidine. The double-blind design ensures that both patients and researchers assessing outcomes remain unaware of group assignments. During the study, patients are monitored for the incidence and severity of nausea and vomiting up to 48 hours after surgery, including the frequency of antiemetic and analgesic use. Additional assessments include pain scores, anxiety and depression scales, and monitoring for adverse effects such as hypotension or skin irritation. The primary outcome is the rate of postoperative nausea and vomiting within the first 24 hours. Overall participation includes preoperative assessments, treatment on the day of surgery, and postoperative follow-up to evaluate safety and efficacy.

Effects of taVNS Combined With Dexmedetomidine on POVN