Actively Recruiting
Effects of tES Combined With CMDT Gait Training on Cognition, Cortical Activity, Spinal Motoneuron Excitability and Motor Performance in Stroke Individuals
Led by Mahidol University · Updated on 2026-02-23
60
Participants Needed
1
Research Sites
105 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The present study will use transcranial electrical stimulation (tES) which are transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS) combined with conventional physical therapy and cognitive-motor dual task gait training in sub-acute (at least 2 weeks after stroke onset) to chronic (within 5 years post-stroke) to investigate the effect on cortical activity, spinal motoneuron excitability, cognition and motor performance. The findings may enhance the evidence to support usages of tES for improvimg cognition, motor performance as well as cortical activity and spinal motoneuron excitability in a clinical setting.
CONDITIONS
Official Title
Effects of tES Combined With CMDT Gait Training on Cognition, Cortical Activity, Spinal Motoneuron Excitability and Motor Performance in Stroke Individuals
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Individuals aged 18 to 80 years with unilateral stroke
- First-ever stroke
- Stroke onset between 2 weeks and 5 years ago
- Able to walk independently with or without gait aids (modified Rankin scale 1-3)
- Montreal Cognitive Assessment-Thai version (MoCA-T) score of 20 or higher
- Able to read, communicate, follow, and understand instructions
You will not qualify if you...
- History of psychological or neurological disorders, unstable medical conditions, epilepsy, seizures, or brain injury
- Unstable cardiovascular or respiratory diseases, or uncontrolled chronic diseases such as diabetes, hypertension, or chronic kidney disease
- Receiving other non-invasive brain stimulation or treatments like TMS, PMS, or acupuncture
- Presence of metal implants, intracranial shunts, cochlear implants, or cardiac pacemakers
- Open or infected wounds on the scalp or unreplaced bone flap after craniectomy
- Moderate joint pain (greater than 4 out of 10) in any upper or lower limb joint
- Color blindness
- Use of substances including cannabis and kratom
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Faculty of Physical Therapy, Mahidol University
Nakhon Pathom, Thailand, 73170
Actively Recruiting
Research Team
W
Wanalee Klomjai, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
TREATMENT
Number of Arms
3
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