Actively Recruiting
Effects of Tobacco Cut and Nicotine Form on the Abuse Liability of Moist Snuff
Led by Ohio State University Comprehensive Cancer Center · Updated on 2025-12-22
80
Participants Needed
2
Research Sites
162 weeks
Total Duration
On this page
Sponsors
O
Ohio State University Comprehensive Cancer Center
Lead Sponsor
N
National Institute on Drug Abuse (NIDA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This clinical trial tests the effects of tobacco cut and nicotine form on the abuse liability in participants who use moist snuff (smokeless tobacco \[SLT\]). Two features of moist snuff that are key targets of manipulation from the tobacco industry and drivers of its addiction potential are length of tobacco cut (long versus fine) and nicotine form (low versus high levels of nicotine in the free-base form). Finer tobacco cuts and higher levels of free-base nicotine (FBN) result in faster, greater nicotine delivery. Researchers want to gain information on how certain characteristics of moist snuff affect how long people use it, how it delivers nicotine, or how much people like it. This clinical trial may provide justifications for local, state, or federal regulations aimed at reducing the appeal and addictiveness of moist snuff.
CONDITIONS
Official Title
Effects of Tobacco Cut and Nicotine Form on the Abuse Liability of Moist Snuff
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 21 years or older
- Daily users of moist snuff for at least the past 3 months
- Use at least 1.5 cans of moist snuff per week
- Reside in Appalachian counties and surrounding rural areas under the RUCA code 10 classification
- Willing to complete 5 study visits and provide informed consent
- Willing to abstain from all tobacco, nicotine, and marijuana for 12 hours before clinic visits
- Ability to read and speak English
You will not qualify if you...
- Pregnant, planning to become pregnant, or breastfeeding (confirmed by urine pregnancy test at first visit)
- Unstable or significant psychiatric conditions (past and stable conditions allowed)
- History of cardiac events or distress, including uncontrolled high blood pressure, chest pain, or shortness of breath within the past 3 months
- Currently working with a cessation counselor, using cessation devices such as Chantix or Wellbutrin, or planning to quit tobacco within the next 3 months
- Severe periodontal disease or oral lesions
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, United States, 43210
Not Yet Recruiting
2
Center for Tobacco Research
Columbus, Ohio, United States, 43214
Actively Recruiting
Research Team
T
The Ohio State Comprehensive Cancer Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
PREVENTION
Number of Arms
5
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