Actively Recruiting
Effects of Tobacco Cut and Nicotine Form on the Abuse Liability of Moist Snuff
Led by Ohio State University Comprehensive Cancer Center · Updated on 2025-12-22
80
Participants Needed
2
Research Sites
48 weeks
Total Duration
On this page
Sponsors
O
Ohio State University Comprehensive Cancer Center
Lead Sponsor
N
National Institute on Drug Abuse (NIDA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying how the characteristics of moist snuff, a type of smokeless tobacco, affect its addictive potential in adults from Appalachian and surrounding rural areas. The study focuses on two key features: tobacco cut length (long versus fine) and nicotine form (levels of free-base nicotine). Understanding how these factors influence tobacco use, nicotine delivery, and user appeal may help guide regulations to reduce addiction risks. Participants take part in five visits where they use different forms of moist snuff. They try their usual brand and four types of moist snuff varying by tobacco cut and free-base nicotine content: low FBN long cut, low FBN fine cut, high FBN long cut, and high FBN fine cut. During each visit, blood samples and carbon monoxide tests are collected to monitor effects. Throughout the study, participants provide information about their tobacco use and undergo various tests to measure nicotine levels and addiction markers. Researchers assess product appeal, effects, and usage patterns over up to two years. The study includes surveys and biological sample collection to evaluate the relationship between tobacco product characteristics and dependence, with ongoing monitoring to ensure safety and adherence.
CONDITIONS
Brief Title
Effects of Tobacco Cut and Nicotine Form on the Abuse Liability of Moist Snuff
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 21 years or older
- Established moist snuff users who have used it daily for at least the past 3 months
- Use at least 1.5 cans of moist snuff per week
- Reside in Appalachian counties and surrounding rural areas classified under RUCA code 10
- Willing to complete 5 study visits and provide informed consent
- Willing to abstain from all tobacco, nicotine, and marijuana for 12 hours before clinic visits
- Ability to read and speak English
You will not qualify if you...
- Pregnant, planning to become pregnant, or breastfeeding (verified by urine pregnancy test at first visit)
- Unstable or significant psychiatric conditions (past stable conditions allowed)
- History of recent cardiac event or distress within past 3 months, including uncontrolled high blood pressure, chest pain, or shortness of breath
- Currently working with a cessation counselor, using cessation devices such as Chantix or Wellbutrin, or planning to quit tobacco within next 3 months
- Severe periodontal or oral lesions
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Five visits over the course of the study
Participants use different types of moist snuff in a randomized order during five separate study visits. At each visit, participants use a specific moist snuff product and undergo blood sample collection and carbon monoxide testing.
5 visits (in-person)
Trial Site Locations
Total: 2 locations
1
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, United States, 43210
Not Yet Recruiting
2
Center for Tobacco Research
Columbus, Ohio, United States, 43214
Actively Recruiting
Research Team
T
The Ohio State Comprehensive Cancer Center
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
PREVENTION
Number of Arms
5
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