Actively Recruiting
The Effects of Tranexamic Acid on Joint Inflammation and Cartilage Health in Anterior Cruciate Ligament Injured Patients
Led by Stanford University · Updated on 2026-02-27
50
Participants Needed
1
Research Sites
389 weeks
Total Duration
On this page
Sponsors
S
Stanford University
Lead Sponsor
U
United States Department of Defense
Collaborating Sponsor
AI-Summary
What this Trial Is About
Patients who tear their ACL are at high risk for developing arthritis (post-traumatic osteoarthritis-PTOA) just 10 years later. Joint bleeding and inflammation contribute to deterioration of joint health. This study will determine whether treatment with Tranexamic Acid (TXA), an FDA approved medication that reduces bleeding right after ACL injury and reconstructive surgery reduces inflammation and improves joint health as a new strategy to prevent or delay the onset of PTOA.
CONDITIONS
Official Title
The Effects of Tranexamic Acid on Joint Inflammation and Cartilage Health in Anterior Cruciate Ligament Injured Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 30 years
- Injury to one ACL within the past 4 days
- Presence of joint swelling or bleeding (effusion/hemarthrosis) in the injured knee
You will not qualify if you...
- Inflammatory arthritis, radiographic osteoarthritis (K-L Grade 2 or higher), gout, or pseudogout
- Systemic or acute illness requiring medications
- Knee injuries besides meniscus or MCL tear that require surgery
- Previous surgery on either knee
- Previous knee injury requiring use of crutches
- History of blood clotting disease (thromboembolic disease)
- Current use of combination hormonal contraception
- Chronic use of NSAID medications
- Cortisone injection in either knee within the last 3 months
- Not suitable for or unable to have ACL reconstruction surgery within 3 months of injury
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Stanford University
Stanford, California, United States, 94305
Actively Recruiting
Research Team
C
Christine L Hoang, BS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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