Actively Recruiting
Effects of Transcranial Direct Current Stimulation on Inhibition and Brain Function in Primary Progressive Aphasia
Led by Centre Hospitalier Universitaire de Nice ยท Updated on 2024-11-05
20
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Primary progressive aphasia (PPA) is a type of dementia mainly affecting language skills. This research evaluates how transcranial direct current stimulation (tDCS), a technique that applies a small electrical current to the brain, may influence brain function and executive abilities in people with PPA. The study also aims to understand brain activity differences between those with PPA and healthy individuals, focusing on markers that might help detect the disorder early. Participants will receive tDCS targeting the dorsolateral prefrontal cortex at 1.5 mA or a sham version where electrodes are placed but the stimulation is minimal and non-continuous. The study is randomized and double-blinded, comparing real stimulation sessions with sham sessions over six weeks. This approach will help assess whether tDCS affects executive function and brain responses. During the study, participants will complete tasks like the Flanker and Stroop tests to measure brain function after six weeks. Researchers will monitor changes in electrophysiological responses and analyze voice and acoustic markers related to symptom changes. Participants must be available for treatment and testing sessions, and the study plans to continue until September 2027.
CONDITIONS
Brief Title
Effects of Transcranial Direct Current Stimulation (tDCS) on Inhibition and Brain Function in Primary Progressive Aphasia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Be a male or female over the age of 18 with a primary progressive aphasia diagnosis
- Available for treatment and testing sessions
- Able to read and speak French
- Be right-handed
You will not qualify if you...
- Presence of neurodevelopmental disorders or non-degenerative neurological disorders
- Post-stroke aphasia
- Language or cognitive disorders too severe to allow task performance or communication
- Pre-existing psychiatric disorders such as severe depression or schizophrenia
- Presence of pacemakers, metal implants, epilepsy
- Medical conditions contraindicating tDCS
- Active use of psychotropic drugs
- Treatment with tDCS or TMS in the last 3 months
- Additional language therapy
- Pregnancy or breast-feeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 6 weeks per treatment period
Participants receive transcranial direct current stimulation (tDCS) or sham stimulation in a crossover design to assess effects on brain function and inhibition.
Multiple treatment sessions during each 6-week period
Trial Site Locations
Total: 1 location
1
CHU de Nice
Nice, France
Actively Recruiting
Research Team
A
Auriane Gros, Pr
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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