Actively Recruiting
Effects of Transcranial Electrical Stimulation on Cognitive Impairment in CNS Inflammatory Demyelinating Diseases
Led by Xuanwu Hospital, Beijing · Updated on 2025-06-19
85
Participants Needed
1
Research Sites
145 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: Central nervous system inflammatory demyelinating diseases often lead to significant cognitive impairment, presenting a critical challenge in patient management. Objective: To evaluate the effectiveness of individualized transcranial electrical stimulation (tES) in improving cognitive function among patients with inflammatory demyelinating disorders. Methods: This study will assess cognitive performance through standardized neuropsychological assessments before and after individualized tES intervention, measuring changes in cognitive domains including memory, attention, executive function, and processing speed. Anticipated Results: the investigators hypothesize that personalized transcranial electrical stimulation will demonstrate significant improvements in cognitive performance, potentially offering a non-invasive therapeutic approach for managing cognitive decline in central nervous system inflammatory demyelinating diseases. Significance: This research may provide novel insights into neuromodulation strategies for cognitive rehabilitation in patients with complex neurological conditions.
CONDITIONS
Official Title
Effects of Transcranial Electrical Stimulation on Cognitive Impairment in CNS Inflammatory Demyelinating Diseases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of Neuromyelitis Optica Spectrum Disorders, Multiple Sclerosis, or other central nervous system inflammatory demyelinating diseases
- SDMT scores less than 55 or subjective cognitive decline
- Age between 18 and 65 years, any gender
- Hamilton Anxiety and Depression Scale scores less than 7 points on both scales
- No relapse or medication changes in the past month
- Expanded Disability Status Scale (EDSS) score of 6 or less
- Right-handed, native Chinese speakers with sufficient education to understand test instructions
- Willingness to participate and signed informed consent
You will not qualify if you...
- Relapse within the past month
- Medication changes within the past month or recent neuromodulation treatments like electroconvulsive therapy or transcranial magnetic stimulation
- Participation in any other clinical research within 1 month prior or currently
- Use of cochlear hearing aids, cardiac pacemakers, or implanted brain stimulation devices
- Skin damage or allergy at electrode placement areas
- History of epilepsy, hydrocephalus, central nervous system tumors, brain injury, or intracranial infections
- Pregnant, lactating, or planning pregnancy soon
- High suicide risk or severe mental illness
- Severe or unstable organic diseases
- Poor compliance preventing cooperation with treatment or data collection
- Other conditions deemed unsuitable by researchers
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Xuanwu Hospital, Capital Medical University
Beijing, China
Actively Recruiting
Research Team
J
Jun wei Hao,MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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