Ilioinguinal/iliohypogastric nerve block.
A Bainton
https://pubmed.ncbi.nlm.nih.gov/7091630Actively Recruiting
Phase Not Applicable
Age: 18Years - 80Years
All Genders
ID07396753
The Effects of Transversalis Fascia Plane Block on Opioid Consumption in Patients Undergoing Hand-Assisted Laparoscopic Donor Nephrectomy A Randomized Controlled Prospective Study
Led by Koç University · Updated on 2026-02-09
50
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating whether the transversalis fascia plane block (TFPB), a regional anesthesia technique, can improve pain control after hand-assisted laparoscopic donor nephrectomy (HALDN), a minimally invasive surgery for living kidney donors. The study aims to see if adding TFPB reduces opioid pain medication use and improves pain relief during the first 24 hours after surgery. This prospective, randomized controlled trial involves adult living kidney donors aged 18 to 80 approved for HALDN. Participants will be randomly assigned to one of two groups. One group will receive standard general anesthesia alone, while the other will receive general anesthesia plus an ultrasound-guided TFPB using 30 mL of 0.25% bupivacaine injected into the lower abdominal wall. All patients will receive standard postoperative pain treatment including paracetamol and patient-controlled morphine. Pain scores and opioid-related side effects will be monitored for 24 hours after surgery. During the study, patients will be assessed for opioid consumption within 24 hours, pain scores using the Numeric Rating Scale every 6 hours, and opioid side effects like nausea or itching. Patient satisfaction with pain control will also be recorded. The trial includes close monitoring of medication use and adverse events to compare pain management effectiveness between groups. Participation involves surgery, anesthesia, postoperative care, and follow-up assessments during the first day after surgery.
CONDITIONS
Brief Title
The Effects of Transversalis Fascia Plane Block on Opioid Consumption in Patients Undergoing Hand-Assisted Laparoscopic Donor Nephrectomy: A Randomized Controlled Prospective Study
Who Can Participate
Age: 18Years - 80Years
All Genders
Eligibility Criteria
You may qualify if you...
- Approved by the transplant committee for living kidney donation
- Scheduled for hand-assisted laparoscopic donor nephrectomy (HALDN)
- Able to understand study procedures and provide written informed consent
- Aged between 18 and 80 years
You will not qualify if you...
- Known allergy to any medications used in the study, including local anesthetics or opioids
- Chronic opioid use or use of opioid receptor agonists
- Inability to communicate effectively, such as due to cognitive impairment or language barriers
- Chronic organ failure or major organ dysfunction
- Refusal or inability to provide informed consent
- Foreign nationality if follow-up or consent is restricted
- American Society of Anesthesiologists (ASA) physical status classification of III or higher
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Surgery and Immediate Post-operative Care
Duration - Day of surgery
Participants undergo hand-assisted laparoscopic donor nephrectomy under general anesthesia. Some participants receive an additional ultrasound-guided transversalis fascia plane block to reduce postoperative pain. After surgery, pain management is provided in the post-anesthesia care unit and surgical ward.
1 surgery day visit including post-anesthesia care unit monitoring
Post-operative Follow-up
Duration - 24 hours after surgery
Participants are monitored for postoperative pain, opioid consumption, and side effects during the first 24 hours after surgery. Pain scores are recorded every 6 hours, and rescue analgesics are provided if needed.
Visits or assessments every 6 hours for 24 hours
Trial Site Locations
Total: 1 location
1
Koç University Hospital
Istanbul, Zeytinburnu, Turkey (Türkiye), 34010
Actively Recruiting
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Research Team
Y
Yasemin Sincer, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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Published Research Related To This Trial
Systematic review and meta-analysis of the effect of nerve block under ultrasound in ilioinguinal/iliohypogastric in children.
Junming Chen, Daiqiang Song, Guifeng Zheng...
https://pubmed.ncbi.nlm.nih.gov/36345442Efficacy and Safety Profile of Rectus Sheath Block in Adult Laparoscopic Surgery: A Meta-analysis.
Hytham K S Hamid, Amjed Y Ahmed, Manhl A Alhamo...
https://pubmed.ncbi.nlm.nih.gov/33387729Pain expectancy, prevalence, severity, and patterns following donor nephrectomy: Findings from the KDOC Study.
Aaron Fleishman, Khalid Khwaja, Jesse D Schold...
https://pubmed.ncbi.nlm.nih.gov/32185880Chronic pain after hand-assisted laparoscopic donor nephrectomy.
M Zorgdrager, M van Londen, L B Westenberg...
https://pubmed.ncbi.nlm.nih.gov/30919435Hand-assisted laparoscopic donor nephrectomy: 1864 cases in 15 years of experience.
Bilal Günaydın, Taha Uçar, Emre Arpalı...
https://pubmed.ncbi.nlm.nih.gov/36326419Effects of erector spinae plane block on opioid consumption in patients undergoing hand-assisted laparoscopic donor nephrectomy: a randomized controlled trial.
Özlem Özkalayci, Muhammet A Karakaya, Yılmaz Yenigün...
https://pubmed.ncbi.nlm.nih.gov/38305014