Actively Recruiting
Effects of Treatments on Atopic Dermatitis
Led by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) · Updated on 2026-05-04
130
Participants Needed
1
Research Sites
745 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: \- Atopic dermatitis, or eczema, is a chronic skin disorder. Patients sometimes have infections with S. aureus bacteria. Researchers want to study how eczema treatments affect the number and the type of bacteria on the skin. Objectives: \- To study the effect of eczema treatments on skin bacteria. Eligibility: * Individuals between 2 and 25 years of age who have moderate to severe atopic dermatitis. * Healthy volunteers between 18 and 40 years of age with no history of eczema. Design: * Participants will be screened with a physical exam and medical history. Research samples will be collected. Skin biopsies may also be performed. * All participants will be assigned to one of several study groups. * Healthy volunteers must not have taken antibiotics in the year before the start of the study. * All participants will have regular study visits during their 1-year participation. More research samples will be collected at these visits. * Healthy volunteers may be asked to come in for a one-time follow up after the 1 year mark.
CONDITIONS
Official Title
Effects of Treatments on Atopic Dermatitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy volunteers aged 18 to 50 years with no history of atopic dermatitis
- Ability and willingness to comply with study procedures and provide informed consent
- Access to bathing facilities (for certain groups)
- Ability to swallow capsules or tablets
- Atopic dermatitis patients aged 2 to 50 years with moderate to severe disease (SCORAD score ≥ 15)
- Diagnosis of atopic dermatitis based on UK Working Party's criteria
- Signs of bacterial skin infection before treatment
- Must have a primary care provider
- Previously enrolled subjects who completed antibiotic regimens and agree to comply with procedures
You will not qualify if you...
- Does not meet inclusion criteria
- Females with symptoms or hormone levels consistent with perimenopause or menopause
- Use of systemic antibiotics in 12 months before baseline (healthy volunteers) or within 8 weeks before baseline (AD patients)
- Use of swimming pools, hot tubs, or whirlpools in 7 days before baseline
- Use of topical or oral complementary/alternative medicine within 4 weeks before treatment
- Known allergies to sulfa, beta-lactam, tetracycline drugs, lidocaine, epinephrine, or sodium hypochlorite
- Family history of toxic epidermal necrolysis
- History of atopic dermatitis or asthma (healthy volunteers)
- Inability to comply with study requirements
- Pregnant or lactating females
- Primary or acquired immunodeficiency including HIV
- Chronic medical illnesses including chronic skin diseases like psoriasis
- Use of investigational drugs, ultraviolet light therapy, monoclonal antibodies, or systemic immunosuppressants
- Healthcare workers or residents in certain healthcare or institutional settings
- Smokers or users of smokeless tobacco products due to unknown effects on skin flora
- Unstable or uncontrolled medical conditions requiring hospitalization (AD patients)
- Recent chemotherapy or radiation therapy within 6 months (AD patients)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
H
Heidi H Kong, M.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
10
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