Comparing Two Exercise Programs Combined With a Mediterranean Diet to Diet Alone in Adults With Obesity and Non-Alcoholic Fatty Liver Disease NAFLD

What this Trial Is About

Researchers are investigating how two different exercise programs combined with a Mediterranean diet compare to the diet alone in reducing inflammation among adults aged 18 to 65 years who have obesity and Non-Alcoholic Fatty Liver Disease NAFLD. The study aims to measure various inflammatory markers and understand the impact on body composition, physical fitness, gut microbiota, quality of life, and fatty acid profiles after a 4-month intervention. Participants will be randomly assigned to one of three groups one group will follow the Mediterranean diet and engage in moderate-intensity aerobic exercise outdoor walking for 180 minutes per week another will follow the diet combined with high-intensity interval training HIIT in a gym setting for 150 minutes per week and the third group will follow the Mediterranean diet alone. All participants will receive guidance from specialized staff on both diet and exercise. During the study, participants will undergo assessments at the start, midpoint, and end of the 4 months, including measurements of systemic inflammation, body composition, gut microbiota analysis, quality of life questionnaires, fatty acid profiles, and evaluations related to sarcopenia risk and intestinal health. The primary outcome focuses on changes in systemic inflammatory status between baseline and day 120. The study will include monitoring to ensure adherence and safety throughout the participation period.

Effects of Two Different Exercise Programs and Diet in Obese Subjects With NAFLD