Actively Recruiting
Effects of Vagus Nerve Pulmonary Branch Block on Postoperative Cough After VATS Lung Resection
Led by Second Affiliated Hospital, School of Medicine, Zhejiang University · Updated on 2024-07-29
104
Participants Needed
1
Research Sites
50 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Postoperative cough after pulmonary resection is a common issue seen after thoracic surgeries, hindering patients' recovery and affecting their postoperative quality of life. While vagus nerve pulmonary branch block has been known to reduce intraoperative coughing, its impact on postoperative cough post lung resection is uncertain. This study aims to assess the effects of vagus nerve pulmonary branch block on postoperative cough after VATS lung resection. A randomized controlled trial involving 104 thoracoscopic lung resection patients will assign them randomly to a vagus nerve pulmonary branch block group or a control group. The primary outcome measure is the postoperative cough incidence 3 weeks after lung resection. The secondary outcomes include assessing hoarseness in PACU, peak expiratory flow (PEF) on the first post-op day, NRS scores for cough, and LCQ-MC scores at 3 weeks post-surgery, as well as cough occurrence, NRS scores, and LCQ-MC scores at 8 weeks post-procedure.
CONDITIONS
Official Title
Effects of Vagus Nerve Pulmonary Branch Block on Postoperative Cough After VATS Lung Resection
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 70 years old.
- Body mass index between 18 and 30 kilograms per square meter.
- ASA Physical Status Classification of I, II, or III.
- Preoperative pulmonary imaging showing peripheral lesions with clinical stage T2, N1, M0.
- Undergoing thoracoscopic lung resection surgery.
- Managed by the same lead surgeon's team.
- Provided informed consent by agreeing and signing the consent document.
You will not qualify if you...
- History of chemotherapy or previous pulmonary surgery.
- Chronic cough caused by respiratory infections, pharyngitis, rhinitis, COPD, asthma, or post-nasal drip syndrome.
- ECG abnormalities such as atrial fibrillation, bundle branch block, frequent ventricular premature beats, or pre-excitation syndrome.
- Current use of ACE inhibitor medications.
- Presence of preoperative hoarseness.
AI-Screening
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Trial Site Locations
Total: 1 location
1
Second affiliated Hospital School of Medicine,Zhejiang University
Hangzhou, Zhejiang, China
Actively Recruiting
Research Team
L
Lina Yu, doctor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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