Actively Recruiting
Effects of Vagus Nerve Pulmonary Branch Block on Postoperative Cough After Thoracoscopic Lung Resection
Led by Second Affiliated Hospital, School of Medicine, Zhejiang University · Updated on 2024-07-29
104
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Postoperative cough is a common problem after lung surgery and can slow recovery and reduce quality of life. Researchers are evaluating the effects of blocking the vagus nerve's pulmonary branch on cough after thoracoscopic lung resection. This randomized controlled trial involves 104 patients undergoing lung resection to understand if this nerve block can reduce coughing after surgery. Participants will be randomly assigned to one of two groups. One group will receive an injection of ropivacaine near the pulmonary branch of the vagus nerve during surgery, while the other group will receive a saline injection as a placebo. Both injections are done under direct thoracoscopic guidance during the operation. Throughout the study, participants will be assessed for cough at 3 and 8 weeks after surgery. Researchers will also measure hoarseness right after surgery, peak expiratory flow on the first day after surgery, and cough intensity using rating scales and questionnaires. The total study participation spans up to 8 weeks post-operation, with multiple follow-ups to monitor outcomes and recovery.
CONDITIONS
Brief Title
Effects of Vagus Nerve Pulmonary Branch Block on Postoperative Cough After VATS Lung Resection
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 70 years old
- Body mass index (BMI) between 18 and 30 kg/m²
- ASA Physical Status Classification of I, II, or III
- Preoperative pulmonary imaging showing peripheral lesions with clinical staging T≤2, N≤1, M0
- Undergoing thoracoscopic lung resection surgery
- Managed by the same lead surgeon's team
- Provided informed consent and signed the consent form
You will not qualify if you...
- History of chemotherapy or previous pulmonary surgery
- Chronic cough from respiratory infections, pharyngitis, rhinitis, COPD, asthma, post-nasal drip syndrome, or similar conditions
- ECG abnormalities such as atrial fibrillation, bundle branch block, frequent ventricular premature beats, pre-excitation syndrome
- Current use of ACE inhibitor medications
- Presence of preoperative hoarseness
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Surgery day and recovery period
Participants undergo thoracoscopic lung resection surgery during which they receive either a vagus nerve pulmonary branch block or a control injection under direct thoracoscopic visualization.
1 surgical procedure visit and immediate post-operative monitoring
Duration - 8 weeks post-operation
Participants are followed for assessment of postoperative cough and related symptoms at 3 and 8 weeks after surgery.
Visits at postoperative day 1, 3 weeks, and 8 weeks
Trial Site Locations
Total: 1 location
1
Second affiliated Hospital School of Medicine,Zhejiang University
Hangzhou, Zhejiang, China
Actively Recruiting
Research Team
L
Lina Yu, doctor
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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