Actively Recruiting
The Effects of a 4-week Supplementation With a Ketogenic Nutrient Mix on 24-hour Substrate Metabolism and Muscle Health
Led by Maastricht University Medical Center · Updated on 2026-02-09
14
Participants Needed
1
Research Sites
100 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will investigate the effect of providing a daily ketogenic nutritional supplement in the evening for a prolonged time (4 weeks) to induce a mild ketogenic state during the night in healthy elderly (60-80 years), overweight/obese (BMI: 25-35 kg/m2) individuals with low physical activity, on 24h rhythmicity in energy metabolism as compared to a non-ketogenic, isocaloric control.
CONDITIONS
Official Title
The Effects of a 4-week Supplementation With a Ketogenic Nutrient Mix on 24-hour Substrate Metabolism and Muscle Health
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 60-80 years
- Body mass index (BMI) 25-35 kg/m2
- Sedentary lifestyle (not more than 2 hours of structured physical activity per week in the past 3 months)
- Stable dietary habits (no weight loss or gain > 5 kg in the past 3 months)
- Healthy (as determined by dependent physician based on medical questionnaire)
- Regular sleeping habits (7-9h of daily sleep)
You will not qualify if you...
- Type 2 diabetes
- Participants with active congestive heart failure and/or severe renal and or liver insufficiency
- Uncontrolled hypertension
- Alcohol consumption of >3 servings per day for men and >2 servings per day for women
- Unstable body weight (weight gain or loss > 5 kg in the last 3 months) or intention to lose weight
- Participants who are on an intermittent fasting diet
- Previous enrolment in a clinical study with an investigational product during the last 3 months or as judged by the investigator which would possibly hamper our study results
- Significant food allergies/intolerance (seriously hampering study meals or study product)
- Participants who do not want to be informed about unexpected medical findings
- Blood donation during or within 2 months prior to the study
- Disturbances in circadian rhythm determined with the follow criteria:
- Extreme early bird or extreme night person (score 60 or 70 on MEQ-SA questionnaire)
- Heavily varying sleep-wake rhythm
- Night shift work during last 3 months
- Travel across > 1 time zone in the last 3 months
- High daily caffeine intake > 400mg (more than 4 cups of coffee or energy drinks)
AI-Screening
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Trial Site Locations
Total: 1 location
1
Maastricht University
Maastricht, Netherlands
Actively Recruiting
Research Team
M
Merel Timmermans, MSc
CONTACT
J
Joris Hoeks, Dr.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
PREVENTION
Number of Arms
2
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