Whole-body Electrical Muscle Stimulation Exercise to Improve Function in Adults with Neuromuscular Diseases

What this Trial Is About

Researchers are evaluating the effects of whole-body electrical muscle stimulation WB-EMS exercise on neuromuscular and physical function in adults with neuromuscular diseases NMD such as amyotrophic lateral sclerosis, spinal muscular atrophy, and myasthenia gravis. People with NMD often face challenges with traditional exercise because of impaired voluntary muscle activation, which can lead to inactivity and worsening health. WB-EMS bypasses these limits by directly stimulating muscle contractions using electrical currents, potentially offering a new way to exercise safely. The intervention uses the Katalyst system, an FDA-cleared device applied off-label, which delivers electrical stimulation to major muscle groups during guided movements. Participants wear a special suit with electrodes connected to an impulse pack controlled via an iPad app. They complete 20-minute supervised exercise sessions 1-2 times per week for 4-8 weeks, following Level 1 strength training videos. Each exercise involves repetitions with stimulation on and off periods, and stimulation levels are adjusted based on participant responses and comfort. Participants will be monitored carefully throughout the study, with evaluations before and after the intervention including neural excitability using transcranial magnetic stimulation, motor unit behavior via electromyography and nerve conduction studies, and functional tests like walking, balance, and strength assessments. Patient-reported outcomes on fatigue, pain, and quality of life will also be collected. Safety monitoring is strict, and the study will provide preliminary data on the feasibility and impact of WB-EMS exercise for adults with NMD.

Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease