Actively Recruiting
Efficacies of Susceptibility-guided vs Empiric Therapy for Rescue Treatment of Helicobacter Pylori Infection
Led by National Taiwan University Hospital · Updated on 2026-04-15
450
Participants Needed
1
Research Sites
242 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The prevalence of H. pylori antibiotic resistance has reached an alarming level worldwide. Antibiotic stewardship programs should be urgently developed and implemented. However, H. pylori antimicrobial susceptibility testing (AST) is rarely offered, making local resistance patterns not easily available. Guideline-recommended empiric therapies (GR-ET) may no longer reliably achieve high cure rate in the era of increasing antibiotic resistance. susceptibility-guided tailored therapy (SG-TT) may be a good choice to solve this problem. The aims of this study are: 1. to compare the efficacy of SG-TT with GR-ET as rescue regimens for H. pylori eradication; 2. to compare the patient adherence and adverse effects of these treatment regimens; 3. to investigate factors that may influence H. pylori eradication by these treatment regimens.
CONDITIONS
Official Title
Efficacies of Susceptibility-guided vs Empiric Therapy for Rescue Treatment of Helicobacter Pylori Infection
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 20 years or older
- Diagnosed with H. pylori-positive chronic gastritis with or without peptic ulcers (duodenal or gastric ulcers)
- Have failed previous anti-H. pylori therapy and are seeking rescue treatment
You will not qualify if you...
- Pregnant or nursing women
- Serious concomitant illnesses or any type of malignant tumor
- History of hypersensitivity to the study drugs
- Serious bleeding during the course of ulcers
- Previous gastric surgery
- Use of bismuth salts, proton pump inhibitors, or antibiotics within the past month
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
National Taiwan University Hospital
Taipei, Taiwan
Actively Recruiting
Research Team
J
Jyh-Chin Yang, M.D.Ph.D.
CONTACT
C
Chien-Chih Tung, M.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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