Comparing Intravenous Acetaminophen Alone to AcetaminophenIbuprofen Combination for Pain Relief After Cesarean Section

What this Trial Is About

Researchers are comparing the pain relief effects of intravenous acetaminophen alone versus a combination of acetaminophen and ibuprofen MaxigesicIV for managing pain after cesarean section. The study focuses on evaluating these treatments as part of multimodal pain management following surgery in women undergoing elective cesarean delivery. Participants will receive either 1 gram of acetaminophen alone or a combination of 1 gram acetaminophen and 300 mg ibuprofen administered intravenously during skin closure at the end of the operation. The same dose is repeated 6 hours after the first administration. This is a randomized, triple-blind trial designed to assess and compare these two pain management approaches. During the study, researchers will assess pain levels at multiple time points after surgery, including 4, 8, 12, 24, and 48 hours, using a numeric rating scale. They will also measure patient-controlled analgesia use and rescue analgesia needs within 24 and 48 hours post-surgery. Other evaluations include wound-related complications, operation and anesthesia duration, and drug effects during and after surgery. The main outcome is the quality of recovery score 24 hours after surgery, with close monitoring throughout the hospital stay.

Efficacy of Acetaminophen Alone Versus Combination of Acetaminophen/Ibuprofen After Cesarean Section