Preventing Uterine Adhesions Using Hyaluronic Acid Gel After Surgical Removal of Retained Pregnancy Tissue

What this Trial Is About

Researchers are evaluating the use of auto-cross linked hyaluronic acid gel to prevent adhesion reformation after hysteroscopic surgery for retained products of conception RPOC. RPOC occurs when placental tissue remains inside the uterus after pregnancy, which can harm future fertility. The study aims to understand if this gel can reduce the risk of intrauterine adhesions, which cause menstrual problems, infertility, and pregnancy loss. After hysteroscopic removal of RPOC, participants are randomly assigned to either receive the hyaluronic acid gel infused into the uterus or not receive the gel. Two additional outpatient hysteroscopies are done at 4 and 8 weeks after surgery to check for adhesions. The experimental group receives the gel treatment while the control group does not. Participants will report their menstrual patterns three months after surgery, and pregnancy outcomes will be followed for 12 months. The main measurements include adhesion rates and scores seen during the third-look hysteroscopy at 8 weeks. Safety is monitored for up to 12 weeks, and the study lasts over a year to track pregnancy success and menstrual changes.

The Efficacy of Auto-cross Linked Hyaluronic Acid Gel in the Prevention of Adhesion Reformation After Hysteroscopic Resection of Retained Products of Conception