Actively Recruiting
Efficacy of Azelastine and Mometasone Irrigation in Comparison to Nasal Sprays in Patients With Chronic Rhinitis
Led by Endeavor Health · Updated on 2023-07-28
81
Participants Needed
1
Research Sites
192 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to determine the best combination of drugs and drug delivery routes to treat surgically naive chronic rhinitis patients. The main question it aims to answer is: Do high volume, high pressure delivery mechanisms in nasal irrigation improve the efficacy of azelastine combined with nasal steroid mometasone as compared to the standard low pressure, low volume delivery mechanisms in nasal sprays? Subjects will complete six months of one of three medication regimens: 1. Saline irrigation followed by azelastine spray and mometasone spray 2. Mometasone saline irrigation 3. Azelastine saline irrigation combined with mometasone saline irrigation.
CONDITIONS
Official Title
Efficacy of Azelastine and Mometasone Irrigation in Comparison to Nasal Sprays in Patients With Chronic Rhinitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 18 years and older seeking treatment for chronic rhinitis and willing to undergo six months of topical therapy
- Diagnosis of Chronic Rhinitis
You will not qualify if you...
- Diagnosis of other conditions causing symptoms such as septal deviation, nasal valve collapse, or chronic sinusitis
- Use of oral antihistamines or oral steroids without a 4 week washout period
- Current smokers including tobacco, marijuana, or vaping
- Known or suspected pregnancy or lactation
- Other medical conditions that may interfere with the study
- Allergy to study drugs
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Northshore University HealthSystem
Evanston, Illinois, United States, 60201
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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