Actively Recruiting
Efficacy of Behavioral Therapy for Chronic Refractory Cough in Patients With Laryngeal Hyperresponsiveness
Led by Assiut University · Updated on 2026-04-23
30
Participants Needed
1
Research Sites
10 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Chronic cough lasting more than eight weeks is a common problem that greatly affects physical, psychological, and social quality of life. Despite treatment of common causes like asthma and gastroesophageal reflux disease, many patients continue to experience persistent symptoms classified under cough hypersensitivity syndrome. This condition is linked to laryngeal hyperresponsiveness, which causes symptoms such as throat irritation, voice changes, frequent throat clearing, and cough triggered by talking or exposure to irritants. The study evaluates behavioral therapy as a non-drug approach for chronic cough in patients with laryngeal hyperresponsiveness. Behavioral therapy involves patient education, cough suppression techniques, breathing retraining, vocal hygiene counseling, and strategies to reduce throat irritation and improve control over the urge to cough. About 30 patients with chronic refractory cough will receive this therapy to assess its effectiveness as a management strategy. Participants will be involved in treatment and monitored over six months to assess outcomes. Researchers will evaluate treatment effects on chronic cough using clinical features and patient responses. The study includes assessments of cough frequency, sensitivity, and quality-of-life impact related to cough. Safety and adherence will be monitored throughout the study, with a focus on improving symptoms related to laryngeal hyperresponsiveness.
CONDITIONS
Brief Title
Efficacy of Behavioral Therapy for Chronic Refractory Cough
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older with a normal chest radiograph
- Chronic cough lasting more than eight weeks that has not improved with standard treatments for common causes such as asthma or gastroesophageal reflux disease
- Clinical signs of laryngeal hyperresponsiveness, including cough triggered by talking, laughter, cold air, or irritants, and symptoms like throat irritation, voice changes, or frequent throat clearing
You will not qualify if you...
- Current smokers or those who quit smoking within the last six months
- Active lung or heart disease, recent respiratory infection, or recent use of angiotensin-converting enzyme inhibitors
- Significant structural problems in the larynx, neurological conditions affecting cough control, or inability to follow study procedures
- Head and neck conditions such as sinusitis, glottal insufficiency, or primary muscle tension dysphonia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 6 months
Participants receive behavioral therapy, including patient education, cough suppression techniques, breathing retraining, vocal hygiene counseling, and strategies to reduce laryngeal irritation and improve cough control.
Regular outpatient visits scheduled during the treatment period
Trial Site Locations
Total: 1 location
1
Assuit University hospitals
Asyut, Egypt
Actively Recruiting
Research Team
M
Mohamed Shaaban Mohamed Mahfouz, Resident
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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