Actively Recruiting
Efficacy of Botox Injection of the Masticatory Muscles in Head &Neck Cancer Patients with Trismus After Radiotherapy
Led by National Taiwan University Hospital · Updated on 2024-12-16
120
Participants Needed
1
Research Sites
61 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Trismus is a common side effect in head and neck cancer patients after radiation therapy. This project aims to explore the therapeutic effect of Botulinum toxin (Botox) injection to the masticatory muscles in the above-mentioned patients. In this project, Botulinum toxin will be injected into the masticatory muscles (medial pterygoid and masticatory muscles), combined with oral rehabilitation exercises, to reduce the patient's masticatory muscle tension and spasm. Patient's mouth opening range, quality of life, trismus condition and pain will be evaluated to understand its efficacy.
CONDITIONS
Official Title
Efficacy of Botox Injection of the Masticatory Muscles in Head &Neck Cancer Patients with Trismus After Radiotherapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged over 18 years old
- Head and neck cancer patients who completed radiotherapy at least 3 months ago
- Mouth opening distance less than or equal to 3.5 cm with tightness or pain in the masticatory muscles
- Stable medical condition
You will not qualify if you...
- Previous surgery on masticatory muscles
- Obvious muscle atrophy or complete fibrosis of masticatory muscles
- Tumor recurrence at the time of admission
- Unstable vital signs due to acute illness
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Taiwan University Hospital
Taipei, Taiwan, 100415
Actively Recruiting
Research Team
D
Dr. Chen
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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