Study Comparing Standard Colonoscopy and Computer-Aided Detection CADe to Reduce Advanced Adenoma Risk Over 3 Years

What this Trial Is About

Researchers are studying the use of computer-aided diagnosis CAD systems during colonoscopy to detect colorectal lesions and potentially reduce the risk of advanced adenomas or interval cancers over three years. The study addresses the challenge of missed lesions during colonoscopy and evaluates whether CAD can improve cancer prevention in patients undergoing colorectal cancer screening. Participants will be randomly assigned during their screening colonoscopy to receive either a standard colonoscopy or a colonoscopy assisted by a CAD system CAD EYE or GENIUS. After the initial procedure, patients will have a follow-up consultation one month later and then a scheduled colonoscopy at three years. For those at higher risk, the three-year follow-up colonoscopy will use the CAD system again, performed by a different investigator who is unaware of previous results. During the study, researchers will monitor outcomes such as the presence of advanced adenomas at 36 months, the number of adenomas detected, and the sensitivity and specificity of the CAD system. They will also evaluate the costs associated with CAD versus standard colonoscopy. Data from routine care colonoscopies will be collected for low-risk patients. The total participation duration extends to at least three years, including follow-up visits and repeat colonoscopies as scheduled.

Efficacy of CAD in Screening Colonoscopy to Reduce the Risk of Advanced Adenoma at 3 Years.