Actively Recruiting
Efficacy and Central Mechanisms of Electroacupuncture for Medication Overuse Headache
Led by Guang'anmen Hospital of China Academy of Chinese Medical Sciences · Updated on 2025-07-16
160
Participants Needed
1
Research Sites
121 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Acupuncture is commonly used for the prevention of migraine and tension-type headaches, and has been found to be effective in reducing both the frequency and severity of these conditions. However, studies on acupuncture for medication overuse headache (MOH) are limited, and current research has not been able to determine whether its efficacy is due to the actual therapeutic effects of acupuncture or psychological benefits. To address this issue, the investigators have designed a clinical trial to evaluate the efficacy of acupuncture for MOH. In addition, the investigators will explore the regulatory effects of electroacupuncture on central mechanisms in MOH and conduct multi-omics analysis.
CONDITIONS
Official Title
Efficacy and Central Mechanisms of Electroacupuncture for Medication Overuse Headache
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Meet the diagnostic criteria of medication overuse headache (MOH) according to ICHD-3
- History of migraine or tension-type headache for at least 12 months before screening
- Completed electronic headache diary data for at least 24 of 28 days during screening
- At least 15 headache days per month during screening and regular overuse of headache medications meeting MOH diagnosis
- Headache started before age 50
- Failed MOH withdrawal treatment at least once in past 3 years
- Aged between 18 and 80 years
- Signed informed consent and agreed to participate
You will not qualify if you...
- History or diagnosis of other headache types such as hypotensive headache, hemiplegic migraine, new daily persistent headache, or other unusual migraine subtypes
- Presence of significant pain syndromes (e.g., fibromyalgia, chronic low back pain) or active temporomandibular joint disorders
- Uncontrolled or untreated serious mental illness or recent history of psychosis or mania
- Medical conditions that interfere with MOH treatment or study compliance
- Use of medications or devices affecting headaches within 3 months before or during screening
- History of moderate/severe head or neck trauma or neurological/systemic diseases affecting CNS function
- Other neurological, pulmonary, hepatic, endocrine, gastrointestinal, hematologic, infectious, immunologic, or ocular diseases associated with symptoms
- History of substance or alcohol abuse within 24 months
- Significant suicide risk
- Received prophylactic headache treatment within 1 month before screening
- Participation in another clinical study or headache medication use within relevant washout periods before screening
- Severe uncontrolled diseases such as cancer, cardiovascular disease, hepatic or renal failure, or coagulopathy
- Pregnant or planning pregnancy
- Fear of acupuncture or acupuncture treatment within 8 weeks before enrollment
- Conditions or medications affecting safety, tolerability, or efficacy assessments as judged by investigators
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Department of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences Guang´anmen Hospital
Beijing, Beijing Municipality, China
Actively Recruiting
Research Team
W
Weiming Wang, Ph.D
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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