Comparing Different NSAIDs for Treating Frozen Shoulder Pain and Movement Problems Role of Pain Types in Treatment Effectiveness in Adults 18 to 75

What this Trial Is About

Researchers are evaluating the effectiveness of different nonsteroidal anti-inflammatory drugs NSAIDs in treating patients aged 18 to 75 years with frozen shoulder adhesive capsulitis who experience shoulder pain and limited movement. The study aims to understand which pain typesnociceptive, neuropathic, or nociplasticbenefit most from various NSAIDs with distinct chemical properties. This trial is conducted in a rehabilitation hospital setting and includes detailed clinical assessments and questionnaires to categorize pain phenotypes. Participants will be randomly assigned to one of three groups receiving different NSAIDs propionic acid derivatives ibuprofen or naproxen, acetic acid derivatives etodolac or diclofenac, or oxicam derivatives meloxicam or lornoxicam. All patients will also follow a home-based exercise program including range-of-motion, Codman, isometric strengthening, and stretching exercises within their pain limits. Treatment response will be assessed after one week using the Visual Analog Scale VAS for pain if effective, the same NSAID continues for another week, otherwise the NSAID is switched. The treatment and exercise program lasts two weeks. Participants will have sociodemographic and clinical data recorded at baseline, and adherence to exercises will be monitored. Pain intensity, shoulder range of motion, and disability will be measured at baseline, week 1, and week 2. Additional assessments include neuropathic pain questionnaires, sleep quality, and patient satisfaction. A blinded evaluator will assess outcomes and monitor any NSAID-related side effects. The study concludes after the two-week treatment and evaluation period, involving a total of 120 patients.

Efficacy of Chemically Distinct Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and Pain Phenotypes in Adhesive Capsulitis