Actively Recruiting
Comparative Efficacy of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) With Distinct Chemical Structures in Shoulder Adhesive Capsulitis and the Role of Pain Phenotypes
Led by Konya Beyhekim Training and Research Hospital · Updated on 2026-05-14
120
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effectiveness of different nonsteroidal anti-inflammatory drugs (NSAIDs) in treating patients aged 18 to 75 years with frozen shoulder (adhesive capsulitis) who experience shoulder pain and limited movement. The study aims to understand which pain types—nociceptive, neuropathic, or nociplastic—benefit most from various NSAIDs with distinct chemical properties. This trial is conducted in a rehabilitation hospital setting and includes detailed clinical assessments and questionnaires to categorize pain phenotypes. Participants will be randomly assigned to one of three groups receiving different NSAIDs: propionic acid derivatives (ibuprofen or naproxen), acetic acid derivatives (etodolac or diclofenac), or oxicam derivatives (meloxicam or lornoxicam). All patients will also follow a home-based exercise program including range-of-motion, Codman, isometric strengthening, and stretching exercises within their pain limits. Treatment response will be assessed after one week using the Visual Analog Scale (VAS) for pain; if effective, the same NSAID continues for another week, otherwise the NSAID is switched. The treatment and exercise program lasts two weeks. Participants will have sociodemographic and clinical data recorded at baseline, and adherence to exercises will be monitored. Pain intensity, shoulder range of motion, and disability will be measured at baseline, week 1, and week 2. Additional assessments include neuropathic pain questionnaires, sleep quality, and patient satisfaction. A blinded evaluator will assess outcomes and monitor any NSAID-related side effects. The study concludes after the two-week treatment and evaluation period, involving a total of 120 patients.
CONDITIONS
Brief Title
Efficacy of Chemically Distinct Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and Pain Phenotypes in Adhesive Capsulitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 75 years
- Shoulder pain lasting at least one month
- Diagnosed with primary frozen shoulder
- Visual Analog Scale (VAS) pain level of 4 or higher out of 10
- At least 30 degrees of range of motion restriction in two or more shoulder directions (flexion, abduction, or external rotation)
- Voluntary agreement to participate with no exclusion criteria present
You will not qualify if you...
- History of shoulder trauma or musculoskeletal disorders causing pain and loss of function in the affected arm
- Neurological conditions such as stroke, brachial plexus injury, Parkinson's disease, or cervical spine injury
- Prior shoulder surgery, malignancy, tumor, or shoulder manipulation
- Shoulder arthritis, rotator cuff tear, other shoulder injuries, or thoracic outlet syndrome
- Systemic diseases affecting the shoulder (e.g., osteoarthritis, rheumatoid arthritis, inflammatory rheumatic diseases)
- Recent steroid injections (within 3 months), current use of oral steroids or NSAIDs, or planned surgical/interventional treatments
- Pregnancy or breastfeeding
- Uncontrolled diabetes, heart failure, liver disease, chronic kidney failure, or significant endocrine disorders
- Communication difficulties or severe psychiatric disorders
- Allergy to NSAIDs or contraindications
- Bleeding or coagulation disorders, stomach ulcers, or symptomatic gastritis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 screening and enrollment visit
Duration - 2 weeks
Participants receive non-steroidal anti-inflammatory drugs (NSAIDs) with distinct chemical properties as analgesic treatment and follow a home exercise program. Pain and functional outcomes are assessed to guide possible switching of NSAIDs after 1 week if needed.
2 visits (in-person) at Week 1 and Week 2
Trial Site Locations
Total: 1 location
1
Konya Beyhekim Training and Research Hospital
Konya, Selçuklu, Turkey (Türkiye), 42000
Actively Recruiting
Research Team
R
Rukiye Hilal Taygurt Md., principal investigator
F
furkan taygurt Md., relative
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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