Actively Recruiting
Efficacy of Combining Ultrasound-Guided Needle Release of Transverse Carpal Ligament and Median Nerve Dextrose Water Hydrodissection for Carpal Tunnel Syndrome
Led by Shin Kong Wu Ho-Su Memorial Hospital · Updated on 2026-04-23
102
Participants Needed
1
Research Sites
260 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Carpal tunnel syndrome (CTS) is a common musculoskeletal disorder, which is caused by compression of the median nerve as it travels through the wrist. There are several treatments for CTS, including conservative and surgical options. Though local corticosteroid injection has been considered more effective than physical therapy for treatment of CTS and has significant short-term benefits, long term benefits are not evidenced. Several studies in recent years reported significantly superior longer-term benefit of D5W and PRP compared with corticosteroid injections and other conservative managements. In addition, percutaneous release of the transverse carpal ligament (TCL) was developed to treat CTS in recent years. Because the effectiveness of the recently developed techniques in treating CTS has not been well established, the investigators aim to investigate whether combining US-guided partial release of the transverse carpal ligament with a needle plus D5W hydrodissection is more beneficial for CTS comparing to either treatment alone.
CONDITIONS
Official Title
Efficacy of Combining Ultrasound-Guided Needle Release of Transverse Carpal Ligament and Median Nerve Dextrose Water Hydrodissection for Carpal Tunnel Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 20 to 80 years old
- Diagnosed with carpal tunnel syndrome based on clinical evaluation and electrophysiological analysis
- Pain or paresthesia severity of 3 or higher on the numeric rating scale
- Symptoms lasting at least 3 months
You will not qualify if you...
- History of polyneuropathy, thoracic outlet syndrome, brachial plexopathy, or inflammatory arthropathy
- Onset of carpal tunnel syndrome during pregnancy, hypothyroidism, or systemic infection
- Previous corticosteroid injection or wrist surgery for carpal tunnel syndrome
- Hypersensitivity to dextrose injection
- Wrist anatomy unsuitable for needle release of the transverse carpal ligament
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Shin Kong Wu Ho-Su Memorial Hospital
Taipei, Taiwan
Actively Recruiting
Research Team
L
Lin-Fen Hsieh
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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