Actively Recruiting
Efficacy of Dengue Infection With Warning Signs Treated With Dexamethasone (DengDex Study)
Led by Chulalongkorn University · Updated on 2025-08-07
200
Participants Needed
2
Research Sites
219 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this randomized double-blinded placebo-controlled trial is to learn about dexamethasone and the treatment of severe dengue population. The main question it aims to answer are steroid therapy may be effective in dengue.
CONDITIONS
Official Title
Efficacy of Dengue Infection With Warning Signs Treated With Dexamethasone (DengDex Study)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Laboratory confirmed dengue infection (Positive NS1 Ag or anti-DENV IgM by Dengue Duo test)
- Currently in febrile phase with body temperature above 37.5°C
- Presence of shock defined by systolic blood pressure below 90 mmHg, narrow pulse pressure less than 20 mmHg, or tachycardia with pulse over 100/min accompanied by a hematocrit decrease of 20% or more
- Signs of fluid accumulation and respiratory distress
- Severe bleeding
- Severe organ involvement
You will not qualify if you...
- Severe dengue symptoms present for more than 24 hours
- Dengue infection without warning signs
- Pregnancy
- Received steroid treatment within the past week
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Chulalongkorn University
Bangkok, Thailand
Actively Recruiting
2
King Chulalongkorn Memorial Hospital
Bangkok, Thailand
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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