Actively Recruiting
The Efficacy of Dexamethasone in Combination With N-acetylcysteine in Preventing Neurocognitive Sequelae Due to Carbon Monoxide Poisoning
Led by China Medical University Hospital · Updated on 2025-03-26
128
Participants Needed
1
Research Sites
131 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background and Aim: Carbon monoxide (CO) poisoning is a significant public health issue that can cause delayed neuropsychological sequelae (DNS). DNS mechanisms involve oxidative stress, inflammation, and immune injury. Although hyperbaric oxygen therapy is widely used, its efficacy in preventing DNS remains inconclusive. Preclinical and retrospective studies suggest that Dexamethasone (anti-inflammatory and immunosuppressive) and N-acetylcysteine (antioxidant) may reduce DNS risk. This study hypothesizes that their combination can effectively prevent DNS. Methods: This prospective pre-post intervention study will enroll CO poisoning patients into treatment (Dexamethasone + N-acetylcysteine) and control groups. The primary outcome is the incidence of DNS within six weeks post-treatment. Objective: To determine whether combining Dexamethasone and N-acetylcysteine reduces the incidence of DNS following CO poisoning.
CONDITIONS
Official Title
The Efficacy of Dexamethasone in Combination With N-acetylcysteine in Preventing Neurocognitive Sequelae Due to Carbon Monoxide Poisoning
Who Can Participate
Eligibility Criteria
You may qualify if you...
- History and clinical symptoms consistent with CO poisoning (initial blood carboxyhemoglobin (COHb) levels >5%, or >10% for smokers).
You will not qualify if you...
- Concurrent use of other potentially lethal toxins.
- Severe trauma or burns that could be fatal.
- No spontaneous heartbeat or blood pressure before arrival.
- Poisoning time exceeding 24 hours before hospital arrival.
- Minors (under 18 years of age).
- Pregnant women.
- Patients or their families refuse to sign the consent form.
- Contraindications for the use of Dexamethasone or N-acetylcysteine such as severe allergies or physician-assessed risks outweighing benefits.
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
China Medical University Hospital
Taichung, Taiwan, 404022
Actively Recruiting
Research Team
C
Chi-Syuan Pan
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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