Comparison of Dexmedetomidine-Propofol Versus Ketamine-Propofol for Sedation During Gastrointestinal Endoscopy

What this Trial Is About

Researchers are evaluating the sedation effectiveness of two drug combinations, Dexmedetomidine-Propofol and Ketamine-Propofol, during upper or lower gastrointestinal endoscopy. The study aims to compare these combinations in terms of maintaining stable blood pressure and heart rate, as well as monitoring postoperative side effects such as delirium, nausea, vomiting, headache, hallucinations, or agitation. This investigation focuses on adults aged 18 to 60 years with relatively healthy physical status. Participants receive sedation with either the Dexmedetomidine-Propofol or the Ketamine-Propofol combination during their gastrointestinal endoscopy procedures. The sedation is given while undergoing either upper or lower gastrointestinal system endoscopy, and the study compares the effects of the two sedation methods. Details about dosing or administration schedule are not provided, but the treatments are studied for their sedation efficacy and safety during the procedure. During the endoscopy, sedation levels are closely monitored every 5 minutes, and after the procedure, monitoring continues every 15 minutes for 2 hours to observe recovery and any side effects. Researchers assess hemodynamic stability and any postoperative symptoms like delirium or nausea. The total participation time includes the endoscopy and the 2-hour postoperative observation period to ensure safety and collect outcome data.

Efficacy of Dexmedetomidine-Propofol Versus Ketamine-Propofol for Sedation