Actively Recruiting
Efficacy of Different Durations of Dual and Quadruple Regimens for Helicobacter Pylori Eradication
Led by Shandong University · Updated on 2024-12-11
330
Participants Needed
1
Research Sites
50 weeks
Total Duration
On this page
Sponsors
S
Shandong University
Lead Sponsor
Z
Zibo Maternal and Child Health Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
The study aimed to compare the efficacy and safety of dual and quadruple regimens with different durations (7-day, 10-day, 14-day) for the eradication of Helicobacter pylori. Subjects were randomized to receive the intervention and were reviewed by 13C-urea breath test after 6 weeks. The eradication rates, adverse reaction rates and patient adherence were calculated.
CONDITIONS
Official Title
Efficacy of Different Durations of Dual and Quadruple Regimens for Helicobacter Pylori Eradication
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18-70 years old
- Confirmed Helicobacter pylori infection by 13C or 14C urea breath test
- No previous treatment for Helicobacter pylori eradication
You will not qualify if you...
- Serious underlying diseases including liver insufficiency (elevated liver enzymes), renal insufficiency (creatinine 652.0 mg/dL or glomerular filtration rate <50 ml/min), immunosuppression, malignant tumors, coronary heart disease or >75% coronary artery stenosis
- Active gastrointestinal bleeding
- History of upper gastrointestinal surgery
- Allergy to treatment drugs
- Use of bismuth or antibiotics within 4 weeks or proton pump inhibitors within 2 weeks before enrollment
- Pregnant or lactating, or unwilling to use contraception during the trial
- Behaviors increasing illness risk such as alcohol or drug abuse
- Unwilling or unable to provide informed consent
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Qilu Hospital of Shandong University
Jinan, Shandong, China, 250012
Actively Recruiting
Research Team
Y
Yanqing Li, Ph.D
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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