Comparing 7-, 10-, and 14-Day Dual and Quadruple Treatments for Helicobacter pylori Infection to Find the Best Eradication Approach

What this Trial Is About

Researchers are evaluating different treatment plans to eradicate Helicobacter pylori infection, comparing dual and quadruple drug regimens with varying durations of 7, 10, and 14 days. The study aims to determine which combination and duration are most effective and safe for patients. This is a Phase 4 randomized controlled trial led by Shandong University. Participants will be randomly assigned to receive one of three treatments a 14-day dual regimen of vonoprazan and amoxicillin, a 10-day dual regimen of the same drugs, or a 7-day quadruple regimen that adds tetracycline and bismuth to vonoprazan and amoxicillin. Each regimen is studied for its ability to clear the infection over these different time frames. During the study, participants will be monitored and tested with a 13C-urea breath test six weeks after treatment to assess eradication success. Researchers will also track any adverse reactions and measure how well patients follow their treatment plans immediately after finishing therapy. The study will last until November 2025 and includes careful monitoring to evaluate both effectiveness and safety outcomes.

Efficacy of Different Durations of Dual and Quadruple Regimens for Helicobacter Pylori Eradication