Actively Recruiting
Efficacy of Dorso-lateral Prefrontal Cortex Stimulation by tDCS in Patients With Motor Conversion Disorder - Multicentre Randomized Double Blind Assay
Led by Centre Hospitalier Universitaire de Nīmes · Updated on 2025-02-13
96
Participants Needed
8
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Conversion disorder, also known as functional neurological disorder, causes impaired voluntary motor or sensory functions not explained by known neurological conditions. It affects up to 30% of patients in neurology hospital departments, with symptoms persisting in 35% of patients even after 12 years. Despite its poor outlook, no validated treatments currently exist. Recent research has focused on brain regions linked to motor conversion disorder, especially the hypoactivation of the left prefrontal dorso-lateral cortex (PFDLC), which is thought to contribute to ongoing motor disability.
CONDITIONS
Brief Title
Efficacy of Dorso-lateral Prefrontal Cortex Stimulation by tDCS in Motor Conversion Disorder Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- The patient must have given informed and signed consent.
- Age between 18 and 65 years.
- The patient is hospitalized or followed in consultation.
- Available for follow-up of 6 months.
- Diagnosed with motor conversion disorder for more than 10 days with initial EDSS score ≥ 3 or WHO score ≥ 2.
You will not qualify if you...
- Participating in another interventional trial.
- Refusal to sign consent.
- Unable to be properly informed.
- Pregnant or breastfeeding.
- Organic neurological involvement found on clinical exam or brain/spinal MRI.
- Current mania, hypomania, substance abuse/dependence (excluding smoking), schizophrenia diagnosis, or severe neurological diseases (epilepsy, stroke, brain tumor).
- Contraindication to MRI (for patients enrolled in Nîmes).
- Acute eczema at electrode locations.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 5 days
Participants receive 10 double-blind transcranial Direct Current Stimulation (tDCS) sessions over 5 days, with two sessions daily spaced 3 hours apart.
10 visits (in-person) over 5 days
Duration - 6 months
Participants are followed to evaluate the efficacy and persistence of treatment effects on motor symptoms and related assessments.
Visits at 7 days, 1 month, 3 months, and 6 months after treatment
Trial Site Locations
Total: 8 locations
1
Centre Hospitalier Universitaire
Nîmes, Gard, France, 30029
Actively Recruiting
2
Hôpital La Colombière Service de Psychiatrie
Montpellier, Hérault, France, 34090
Not Yet Recruiting
3
CHU de Montpellier Hôpital Gui De Chauliac Service de Neurologie
Montpellier, Hérault, France, 34295
Not Yet Recruiting
4
Hôpital Lapeyronie
Montpellier, Hérault, France, 34295
Not Yet Recruiting
5
Hospices Civils de Lyon Hôpital Edouard Herriot
Lyon, France, 69003
Not Yet Recruiting
6
CHU de Nantes
Nantes, France, 44000
Not Yet Recruiting
7
Clinique St Exupery
Toulouse, France, 31000
Not Yet Recruiting
8
Hôpital Saint-Antoine Service de Psychiatrie APHP
Paris, Île-de-France Region, France, 75012
Not Yet Recruiting
Research Team
I
Ismael CONEJERO, Dr.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here