Trends in risk factors, patterns and causes in hospitalized strokes over 25 years: The Lausanne Stroke Registry.
Emmanuel Carrera, Malin Maeder-Ingvar, Andrea O Rossetti...
https://pubmed.ncbi.nlm.nih.gov/17519551Actively Recruiting
Phase Not Applicable
Age: 18Years +
All Genders
ID05644314
Efficacy of Drug-Eluting Vertebral Artery Stenting Treatment for Atherosclerotic Vertebral Arteries Stenosis in Real-World Clinical Observations: a Prospective, Multicenter, Open-access, Single-arm Clinical Study
Led by Nanfang Hospital, Southern Medical University · Updated on 2023-03-14
144
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to observe the real-world effectiveness of a drug-eluting vertebral artery stenting system in treating atherosclerotic vertebral artery stenosis, a significant cause of ischemic strokes affecting the brain's posterior circulation. Stroke remains a leading cause of disability and death worldwide, with many strokes occurring in the vertebral arteries, which are crucial for brain blood flow. This study focuses on patients with symptomatic or non-symptomatic vertebral artery stenosis, evaluating the long-term impact of the treatment beyond previous clinical trials.
CONDITIONS
Brief Title
Efficacy of Drug-Eluting Vertebral Artery Stenting Treatment for Atherosclerotic Vertebral Arteries Stenosis
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Patients prescribed medically with rapamycin drug-eluting vertebral artery stent systems
- Patients and family members fully understand the trial's purpose, voluntarily participate, and sign the informed consent form
You will not qualify if you...
- Unable to receive dual antiplatelet therapy due to known disease
- Severe coagulation abnormalities
- Severe infections that are not controlled
- Severe systemic disease or uncontrollable hypertension
- Contraindications for surgery
- Presence of aneurysm that cannot be treated earlier or simultaneously or is unsuitable for surgery
- Active gastrointestinal bleeding
- Previous myocardial infarction or large-scale cerebral infarction within 2 weeks
- Known contraindications to heparin, rapamycin, anesthesia, or contrast agents
- Life expectancy less than 12 months
- Investigator judged patients unsuitable for participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Implementation
Duration - Single procedure with follow-up
Participants receive the drug-eluting vertebral artery stent implantation as treatment for vertebral artery stenosis.
1 implantation visit (in-person)
Post-operative Follow-up
Duration - Up to 3 years
Participants are monitored to assess clinical success, adverse events, restenosis, and changes in neurological scores after stent implantation.
Visits at 1 month, 6 months, 12 months, 2 years, and 3 years
Trial Site Locations
Total: 1 location
1
Nanfang Hospital of Southern Medical University
Guangzhou, Guangdong, China, 510515
Actively Recruiting
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Research Team
Z
Zhong Ji, PHD
K
Kaibin Huang
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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Published Research Related To This Trial
Incidence and prognosis of > or = 50% symptomatic vertebral or basilar artery stenosis: prospective population-based study.
L Marquardt, W Kuker, A Chandratheva...
https://pubmed.ncbi.nlm.nih.gov/19293244Embolism from vertebral artery origin occlusive disease.
L R Caplan, P Amarenco, A Rosengart...
https://pubmed.ncbi.nlm.nih.gov/1641144Stroke risk after posterior circulation stroke/transient ischemic attack and its relationship to site of vertebrobasilar stenosis: pooled data analysis from prospective studies.
Giosue Gulli, Lars Marquardt, Peter M Rothwell...
https://pubmed.ncbi.nlm.nih.gov/23386676Vertebrobasilar stenosis predicts high early recurrent stroke risk in posterior circulation stroke and TIA.
Giosué Gulli, Sofia Khan, Hugh S Markus
https://pubmed.ncbi.nlm.nih.gov/19478210Clopidogrel with aspirin in acute minor stroke or transient ischemic attack.
Yongjun Wang, Yilong Wang, Xingquan Zhao...
https://pubmed.ncbi.nlm.nih.gov/23803136A systematic review of stenting and angioplasty of symptomatic extracranial vertebral artery stenosis.
Aaron N Stayman, Raul G Nogueira, Rishi Gupta
https://pubmed.ncbi.nlm.nih.gov/21700936Stenting for symptomatic vertebral artery stenosis: a preplanned pooled individual patient data analysis.
Hugh S Markus, Eric L Harshfield, Annette Compter...
https://pubmed.ncbi.nlm.nih.gov/31130429Percutaneous transluminal angioplasty and stenting in patients with proximal vertebral artery stenosis.
George A Antoniou, David Murray, George S Georgiadis...
https://pubmed.ncbi.nlm.nih.gov/22206680Bare metal vs. drug-eluting stents for extracranial vertebral artery disease: a meta-analysis of nonrandomized comparative studies.
Nicolas Langwieser, Dominique Buyer, Tibor Schuster...
https://pubmed.ncbi.nlm.nih.gov/25290797