Efficacy of the Entire Papilla Preservation Technique With and Without the Use of L-PRF as a Regenerative Material for the Treatment of Infrabony Defects A Randomized Controlled Clinical Trial

What this Trial Is About

This research aims to evaluate the use of L-PRF leukocyte and platelet rich fibrin combined with the Entire Papilla Preservation EPP surgical technique for treating interproximal intraosseous periodontal defects. The study compares outcomes of the EPP technique with and without L-PRF in patients with periodontitis, focusing on clinical and radiographic periodontal parameters. It also assesses postoperative complications and sensitivity, addressing the need for minimally invasive and affordable treatments for severe periodontal disease. The trial involves 30 patients with periodontal defects treated using the EPP technique. Half of the patients will have their defects filled with L-PRF, an autologous blood-derived material that may aid healing and reduce inflammation, while the other half will receive the procedure without any filling material. Both groups will be evaluated at the start and 6 months after surgery. The L-PRF is prepared through centrifugation of the patients own blood and applied as a filling to the defect site. Participants will undergo clinical evaluations including plaque index, bleeding on probing, probing depth, attachment levels, gingival margin position, and papilla measurements before surgery and 6 months later. Radiographic assessments using CBCT scans will measure defect size and healing. Patients will report pain levels 24 hours and 7 days post-surgery. Researchers will monitor healing progress, effectiveness of the procedure, and any complications over the 6-month follow-up period.

Efficacy of the Entire Papilla Preservation Technique With and Without the Use of L-PRF as a Regenerative Material for the Treatment of Infrabony Defects