Actively Recruiting
Efficacy of Esketamine for Patients With Irritable Bowel Syndrome
Led by Beijing Tiantan Hospital · Updated on 2025-09-10
552
Participants Needed
1
Research Sites
119 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To explore the efficacy of a single low dose of esketamine for patients with irritable bowel syndrome (IBS).
CONDITIONS
Official Title
Efficacy of Esketamine for Patients With Irritable Bowel Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 60 years
- American Society of Anesthesiologists physical status of I or II
- Body Mass Index between 15 and 30
- Scheduled for colonoscopy
- Positive diagnosis of IBS by Rome IV criteria
- Diagnosis of anxiety disorder and/or major depressive disorder by DSM-5 criteria
You will not qualify if you...
- Gastrointestinal bleeding
- Any organic lesions found by clinical exams, lab tests, or colonoscopy
- Previous diagnosis of colon cancer, inflammatory bowel disease, or celiac disease
- Weight loss of 10% or more in the past six months
- History of abdominal surgery except hernia repair or appendectomy
- Participation in other clinical trials within the last 3 months
- Age over 55 without a colonoscopy in the past 5 years
- Severe personality disorder, active suicidal thoughts, or self-harm in the past year
- Allergy or contraindications to study drugs including severe cardiovascular disease, refractory hypertension, or hyperthyroidism
- Drinking more than 50 units of alcohol per week
- Pregnancy or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Beijing Tiantan Hospital
Beijing, Beijing Municipality, China, 100050
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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