Actively Recruiting
Efficacy of Hi-tACS for Schizophrenia Negative Symptoms
Led by Shanghai Mental Health Center · Updated on 2025-06-04
60
Participants Needed
1
Research Sites
126 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to investigate whether Hi-tACS is effective and safe in treating negative symptoms of schizophrenia. Schizophrenic patients will receive treatment (Hi-tACS or shame stimulation) for 2 weeks. Negative symptoms, cognitive functioning, social functioning, and quality of life of intervention group and control group were assessed and compared between the two groups at baseline, 2 weeks, and 3 months post-intervention.
CONDITIONS
Official Title
Efficacy of Hi-tACS for Schizophrenia Negative Symptoms
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Han Chinese population
- Age 18 years or older
- At least 6 years of education and able to complete questionnaires and examinations
- Diagnosed with schizophrenia according to DSM-5 using MINI 7.0
- Presence of residual negative symptoms with at least one item scoring 2 or higher on PANSS negative subscale
- Taking second-generation atypical antipsychotic medication with no recent dosage changes in the last two weeks
- Provided informed consent along with guardian agreement
You will not qualify if you...
- Diagnosed with other mental disorders according to DSM-5
- PANSS positive subscale total score 19 or higher
- Severe negative symptoms preventing participation in assessments or treatments
- Serious physical or central nervous system diseases including intracranial infections, tumors, epilepsy, implanted electronic devices, serious cardiac disease with pacemaker
- Skin problems or allergies at electrode placement sites
- Mental retardation (WAIS below 70) or severe cognitive impairment (MMSE below 24)
- Vision or hearing problems interfering with tests
- Alcohol or drug abuse or dependence
- Pregnancy
- Participation in other clinical studies within the last 3 months
- Refusal or failure to sign informed consent form
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Shanghai Mental Health Center
Shanghai, Shanghai Municipality, China, 200030
Actively Recruiting
Research Team
Q
Qing Fan, Doctor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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