Actively Recruiting
Efficacy and Influencing Factors of Mindfulness-Based Exposure Group Therapy for OCD
Led by Shanghai Mental Health Center · Updated on 2026-03-20
64
Participants Needed
1
Research Sites
177 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Obessive-Compulsive Disorder (OCD) is frequently treatment-refractory and imposes a substantial burden on affected individuals. Although Exposure and Response Prevention (ERP) is widely regarded as the first-line intervention, its inherently distressing nature contributes to treatment refusal and premature dropout in a subset of patients. The present study aims to develop and validate a novel intervention, Mindfulness-Based Exposure Therapy (MBET). In contrast to existing protocols that incorporate mindfulness as an adjunct to ERP and have yielded mixed or limited benefits, this study seeks a theoretically grounded integration of mindfulness and exposure-based principles. We hypothesize that mindfulness training improves emotion regulation, thereby producing a synergistic effect that enhances patients' capacity to engage in and complete exposure tasks. From a clinical perspective, MBET is intended to offer a more tolerable and acceptable alternative to standard ERP, with the potential to improve treatment adherence and clinical outcomes among patients who experience traditional exposure procedures as excessively distressing.
CONDITIONS
Official Title
Efficacy and Influencing Factors of Mindfulness-Based Exposure Group Therapy for OCD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have a primary diagnosis of Obsessive-Compulsive Disorder (OCD) according to DSM-5 criteria
- Are between 16 and 55 years of age (inclusive)
- Have a Yale-Brown Obsessive Compulsive Scale (Y-BOCS) total score 16
- Have an education level of junior high school or above
- Are medication-free or have been stabilized on psychotropic medication for at least 8 weeks
- Have sufficient visual and auditory capabilities to complete study assessments
- Are willing to participate and provide written informed consent
You will not qualify if you...
- Meet DSM-5 criteria for any other psychiatric disorder besides OCD
- Have severe OCD symptoms that prevent completion of assessments
- Exhibit active suicidal ideation or high suicide risk
- Have a serious somatic disease, central nervous system disease, or substance abuse history
- Are pregnant, breastfeeding, or planning pregnancy
- Have metal implants contraindicated for MRI (e.g., pacemakers, intracranial clips, metal dentures, arterial stents, joint fixations)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Shanghai mental health center
Shanghai, Shanghai Municipality, China, 200030
Actively Recruiting
Research Team
Z
Zhen Wang, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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