Actively Recruiting
Efficacy of Intra-Ureteric Aminophylline Installation After Failed Stone Accessibility by Semi-rigid Ureteroscopy Prospective Trial
Led by Al-Azhar University · Updated on 2024-12-11
300
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Urolithiasis, or urinary tract stones, is a common condition worldwide with increasing prevalence in people over 30 years old. This trial investigates the use of local aminophylline instillation into the ureter during ureteroscopy, aiming to improve stone access without the need for balloon dilation. The study evaluates whether aminophylline can relax the ureter and reduce complications during stone removal procedures. Participants will initially undergo direct semi-rigid ureteroscopy without balloon dilation. If the ureteroscope cannot advance, 20 ml of aminophylline will be instilled locally through a ureteric stent. After 10 minutes, another attempt to pass the ureteroscope will be made to assess success. This method is being studied as a possible alternative to balloon dilation during ureteroscopic stone treatment. During the study, researchers will monitor the success rate of ureteral access and stone scoping from the start to the end of the procedure. They will also evaluate the complete extraction of stones. The study includes follow-up assessments related to the procedure's success and safety. Participants will be involved in the procedure and monitored throughout, with the total participation duration based on the procedure timeline.
CONDITIONS
Brief Title
Efficacy of Intra-Ureteric Aminophylline Installation After Failed Stone Accessibility by Semi-rigid Ureteroscopy. Prospective Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with failed stone accessibility by semi-rigid ureteroscopy
- Adults aged 18 years or older
You will not qualify if you...
- Children
- Patients with a pre-existing ureteric stent
- Hypersensitivity or contraindications to aminophylline
- Pregnant or breastfeeding women
- Active urinary tract infection
- Contraindications to ureteroscopy such as uncorrected bleeding disorders or inability to undergo general/spinal anesthesia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single procedure visit
Participants undergo semi-rigid ureteroscopy. If initial access to the stone fails, aminophylline is instilled intra-ureterically to help facilitate ureteroscope advancement and stone access.
1 treatment visit (in-person)
Trial Site Locations
Total: 1 location
1
Al-Azhar university, faculty of medicine, the urology department
Cairo, Egypt
Actively Recruiting
Research Team
M
Mohamed Fawzy Mohamed Fawzy Salman, MD
M
Mohamed Fawzy Salman, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
1
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