Testing Intramuscular Steroid Injection to Treat Unexplained Chronic Cough in Adults Randomized, Placebo-Controlled Trial Evaluating Effectiveness and Safety

What this Trial Is About

This trial investigates whether intramuscular steroid injections can effectively treat unexplained chronic cough, a condition thought to involve nerve and larynx inflammation. The study compares steroid injections against placebo in a randomized, single-blind design to determine if steroid treatment reduces cough severity and improves symptoms. Researchers aim to find an accessible, evidence-based treatment option for patients with this challenging condition. Participants are randomly assigned to receive either a triamcinolone steroid injection or a saline placebo injection into the deltoid muscle. The study focuses on the systemic effects of steroids, based on theories that neuroinflammation drives chronic cough and that treatment site may not be critical. The trial duration includes a 4-week period after injection to evaluate symptom changes. During participation, patients complete questionnaires including the Leicester Cough Questionnaire and visual analog scales to assess cough severity and improvement. Researchers also record a simple yesno response to symptom change and monitor any adverse reactions. Data collected over 4 weeks will help determine the treatments impact, with safety and effectiveness measured carefully throughout the study.

Efficacy of Intramuscular Steroid Injection for Chronic Cough.