Prospective Placebo-Controlled Trial of Intramuscular Steroid Administration for the Treatment of Unexplained Chronic Cough

What this Trial Is About

Researchers are evaluating whether injecting steroids into the muscle can effectively treat unexplained chronic cough, a condition where the cause of persistent cough is unknown. This trial is designed as a prospective, placebo-controlled, single-blind, randomized clinical study comparing steroid injections to placebo. The study aims to find out if these injections improve symptoms by measuring patient responses, cough-specific questionnaires, and symptom severity scores, while also documenting any side effects. Participants will be randomly assigned to receive either a steroid injection called Triamcinolone Acetonide or a saline injection into the deltoid muscle of the arm. The treatment is given as a one-time injection in the deltoid muscle, and the study will compare the outcomes between the two groups to see if steroid injections provide significant relief. This approach may offer a more accessible treatment option than nerve injections typically done by specialists. During the study, participants will be assessed over four weeks using the Leicester Cough Questionnaire, a visual analog scale for symptom severity, and a simple yes/no measure of symptom improvement. Researchers will carefully monitor for any adverse reactions. The total participation time includes the initial injection and follow-up evaluations over a one-month period to assess treatment effects and safety.

Efficacy of Intramuscular Steroid Injection for Chronic Cough.