Evaluating Laser Interstitial Thermal Therapy LITT for Treating Recurrent or Progressive Low-grade Gliomas in Children, Adolescents, and Young Adults

What this Trial Is About

Researchers are evaluating the use of Laser Interstitial Thermal Therapy LITT to treat children, adolescents, and young adults with recurrent or progressive low-grade gliomas LGGs. The study aims to determine how many patients remain free from disease progression 15 months after receiving LITT. Additional goals include assessing the safety and side effects of LITT, along with measuring response rates, duration of response, time to next treatment, and impacts on tumor cysts and seizure frequency. Participants will receive LITT as the main treatment, with imaging and questionnaires completed before the procedure and again at 3 months, 1 year, and 2 years afterward. Close monitoring occurs immediately following the procedure, including safety follow-up visits at 14 and 28 days. Imaging data will be collected for up to 24 months, and participants will also join an additional protocol PNOC COMP for continued follow-up until death or withdrawal. During the study, participants will undergo scheduled MRI scans and complete questionnaires to evaluate treatment effects and quality of life. Researchers will track tumor progression, seizure frequency, and the need for medications to manage complications like edema. Follow-up extends over two years post-LITT, with ongoing monitoring under the PNOC COMP protocol, aiming to capture long-term outcomes and safety data.

Efficacy of Laser Interstitial Thermal Therapy in Young Persons With Low-grade Glioma