Actively Recruiting
Efficacy of Liposomal Bupivacaine for Transversus Abdominis Plane Block
Led by Tianjin First Central Hospital · Updated on 2026-05-14
86
Participants Needed
1
Research Sites
11 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a single-center, randomized, single-blind, parallel-group clinical trial. The study aims to compare the analgesic efficacy of liposomal bupivacaine versus ropivacaine for transversus abdominis plane (TAP) block in patients undergoing laparoscopic cholecystectomy. Eligible participants will be randomly assigned to receive either liposomal bupivacaine or ropivacaine for TAP block during surgery. The primary outcome is the dynamic NRS pain score at 24 hours after surgery. Secondary outcomes include static and dynamic NRS pain scores at multiple time points, QoR-15 recovery quality, time to first rescue analgesia, analgesic consumption, gastrointestinal function recovery, length of hospital stay, and adverse events. Participants will be followed up to 3 months after surgery to evaluate the incidence of chronic post-surgical pain (CPSP). All participants will receive routine clinical care, and participation is voluntary.
CONDITIONS
Official Title
Efficacy of Liposomal Bupivacaine for Transversus Abdominis Plane Block
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 65 years, any gender
- Scheduled for elective laparoscopic cholecystectomy
- ASA physical status I to III
- Able to provide written informed consent and complete 3-month follow-up
You will not qualify if you...
- Allergy to local anesthetics
- History of dementia, psychosis, or other central nervous system diseases
- History of chronic pain or long-term opioid or analgesic use
- Contraindications to nerve block such as infection at puncture site or severe coagulopathy
- Severe liver or kidney dysfunction, pregnancy, or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Tianjin First Central Hospital
Tianjin, Tianjin Municipality, China, 300384
Actively Recruiting
Research Team
K
Ke yu Zhang
CONTACT
L
Lili Jia
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here