Actively Recruiting
Efficacy and Mechanism of Augmentation of Cognitive Behavioral Therapy With Transcranial Alternating Current Stimulation(tACS) for Obsessive-Compulsive Disorder (OCD)
Led by Shanghai Mental Health Center · Updated on 2025-08-01
62
Participants Needed
1
Research Sites
193 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to evaluate the feasibility and clinical outcome of the Exposure-based Cognitive-Behavioral Therapy (CBT) concurrent with Transcranial Alternating Current Stimulation (tACS) using individualized stimulation frequency in treating obsessive-compulsive disorder (OCD) patients, and explores the potential neural mechanisms of treatment effect by magnetic resonance imaging (MRI) and electroencephalography (EEG).
CONDITIONS
Official Title
Efficacy and Mechanism of Augmentation of Cognitive Behavioral Therapy With Transcranial Alternating Current Stimulation(tACS) for Obsessive-Compulsive Disorder (OCD)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 60 years
- At least 9 years of education
- Yale-Brown Obsessive Compulsive Scale (Y-BOCS) score of 16 or higher
- Confirmed diagnosis of OCD by Mini-International Neuropsychiatric Interview (MINI)
- No serious medical, neurological illness or other psychotic disorders except anxiety or mild to moderate depression secondary to OCD
- Medication-free or stable medication use for at least 8 weeks before the study and continued during the study
You will not qualify if you...
- History of serious medical, neurological illness or other psychotic disorders except OCD
- OCD symptoms severe enough to prevent completing assessments and examinations
- Serious suicide risk
- Pregnant or planning pregnancy
- Currently taking antiepileptic medication
- Clinically significant physical illnesses or abnormal lab tests
- Previously completed a full course of CBT/ERP treatment
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Shanghai Mental Health Center
Shanghai, Shanghai Municipality, China, 200030
Actively Recruiting
Research Team
Z
Zhen Wang, PhD, MD
CONTACT
Z
Zhen Wang, PhD, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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