Actively Recruiting
Efficacy and Mechanism of rTMS on the Symptoms of Pleasure Deficit in Adolescent Depression
Led by Xijing Hospital · Updated on 2024-09-23
44
Participants Needed
1
Research Sites
68 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
(1) Primary objective: to collect data on the score of pleasure deficit scale before and after repetitive transcranial magnetic stimulation treatment in adolescent depressed patients, and to verify its efficacy and safety in adolescent depressed patients in combination with the changes of clinical symptoms; (2) Secondary objective: to explore the relevant hemodynamic mechanisms in adolescent depressed patients before and after repetitive transcranial magnetic stimulation treatment.
CONDITIONS
Official Title
Efficacy and Mechanism of rTMS on the Symptoms of Pleasure Deficit in Adolescent Depression
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 10 to 19 years old, any gender
- Diagnosed with major depressive disorder according to DSM-5
- First episode or relapse of monophasic or bipolar depressive disorder
- No antidepressant treatment (medication, physical, or psychotherapy) within 2 weeks before enrollment
- Right-handed
- Pleasure deficit scale (DARS) score below 22 points
- Hamilton Depression Scale (HAMD-17) score above 17
- Willing to cooperate with treatment and signed informed consent after understanding rTMS safety
You will not qualify if you...
- Presence of psychotic symptoms
- Major psychiatric disorders such as schizophrenia, delusional disorder, delirium, neurocognitive disorder, intellectual disability, or other disease-related mental disorders
- History of primary neurological disease or brain injury
- History of electroconvulsive therapy
- Contraindications to rTMS including cardiac pacemakers, neurostimulators, metal heart valves, intracranial aneurysm clips, cochlear implants, or other metal implants except oral supports
- History of epilepsy
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
XijingH
Xi'an, Shaanxi, China, 710032
Actively Recruiting
Research Team
S
Siheng Ma
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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