Actively Recruiting
Efficacy and Mechanisms of Virtual Reality Treatment of Phantom Leg Pain.Home-Based Treatment
Led by Albert Einstein Healthcare Network · Updated on 2025-08-08
44
Participants Needed
3
Research Sites
49 weeks
Total Duration
On this page
Sponsors
A
Albert Einstein Healthcare Network
Lead Sponsor
U
University of Pennsylvania
Collaborating Sponsor
AI-Summary
What this Trial Is About
After amputation of an arm or leg, up to 90% of subjects experience a "phantom limb", a phenomenon characterized by persistent feelings of the missing limb. Many subjects with a phantom limb experience intense pain in the missing extremity that is often poorly responsive to medications or other interventions. The study will explore the feasibility and efficacy of a home-based, active VR treatment for phantom limb pain (PLP).
CONDITIONS
Official Title
Efficacy and Mechanisms of Virtual Reality Treatment of Phantom Leg Pain.Home-Based Treatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 100 years
- Ability to provide informed consent
- Unilateral above or below knee amputation at least 3 months before enrollment
- Montreal Cognitive Assessment score of 18 or higher indicating no significant cognitive impairment
- Average phantom limb pain greater than 4 on a 0-10 scale over the past month
You will not qualify if you...
- History of significant medical or neurological disorders such as stroke or moderate to severe traumatic brain injury
- Significant or poorly controlled psychiatric disorders
- Substantial depression or anxiety that affects ability to perform study tasks
- Current abuse of alcohol or drugs
- Nursing, pregnant, or planning to become pregnant during the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Jefferson Moss Rehabilitation Research Institute
Philadelphia, Pennsylvania, United States, 19027
Actively Recruiting
2
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19122
Actively Recruiting
3
University of Washington
Seattle, Washington, United States, 98195
Actively Recruiting
Research Team
L
Laurel Buxbaum
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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