Actively Recruiting
Efficacy of Metformin as an Adjunct to Standard Antidepressant Therapy in Treating Depression Among Obese Patients
Led by Fazaia Ruth Pfau Medical College · Updated on 2025-09-19
140
Participants Needed
2
Research Sites
60 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To evaluate the efficacy of metformin as an adjunct therapy in improving depressive symptoms and metabolic markers in newly diagnosed obese depressed patients on standard antidepressant therapy. investigator will compare between Two groups 1\. metformin group 2 placebo group Primary outcome measure will be the improvement in depressive symptoms, indicating by a reduction in Hamilton Depression Rating Scale (HAM-D) scores. Secondary outcome measures will include the assessment of oxidative stress markers, specifically by measuring the increase in enzymatic activity of superoxide dismutase, catalase, and glutathione peroxidase Investigators hypothesize that the addition of metformin to standard antidepressant treatment will result in a significant reduction in symptoms of depression among newly diagnosed obese individuals.
CONDITIONS
Official Title
Efficacy of Metformin as an Adjunct to Standard Antidepressant Therapy in Treating Depression Among Obese Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age over 18 and under 45 years
- Both male and female genders
- Body mass index (BMI) greater than 25
- Newly diagnosed cases of mild to severe depression
- HbA1c less than 5.7% (non-diabetic range)
You will not qualify if you...
- Existing diabetes
- Acute illnesses such as acute kidney injury, recent heart attack, or acute liver injury
- Intellectual disabilities or inability to understand the study
- Psychiatric disorders other than depression
- Chronic kidney disease with eGFR below 45 mL/min/1.73 m²
- Use of any psychotropic medication within the past 6 months
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Fazaia Rurh Pfau Medical College
Karachi, Sindh, Pakistan, 75120
Actively Recruiting
2
Fazaia Ruth Pfau Medical College
Karachi, Sindh, Pakistan, 75120
Actively Recruiting
Research Team
S
Sadia khan, MBBS
CONTACT
A
Asghar Mehdi, MBBS,PHD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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