Actively Recruiting
Efficacy of Methylprednisolone for Pain Control After ACL Repair
Led by St. Louis University · Updated on 2025-10-24
90
Participants Needed
1
Research Sites
305 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Opioids are commonly used after orthopedic surgery for pain control but have been shown to increase complications, surgeries, readmissions, and risk for opioid use disorder. The purpose of this study is to investigate the impact of adding a methylprednisolone taper to the pain regimen after ACL repair surgery to determine if this results in decreased postoperative pain and opioid use without increasing complications.
CONDITIONS
Official Title
Efficacy of Methylprednisolone for Pain Control After ACL Repair
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient undergoing ACL repair or ACL reconstruction with tendon autograft
- Age 13-50 years old
- Able to provide informed consent or parent/legal guardian is able for minors
You will not qualify if you...
- Concurrent and significant injury to other bones or organs (Injury Severity Score of 4 or greater)
- Revision ACL reconstruction
- Concomitant additional ligament reconstruction or high tibial osteotomy
- History of alcohol abuse, substance abuse or chronic opioid use within 6 months before surgery
- History of renal failure, liver dysfunction, severe heart disease, diabetes, neurological or psychiatric diseases affecting pain perception, or immune suppression
- History or active peptic ulcer disease, gastrointestinal bleeding, or current use of anticoagulation
- Current or recent use of oral or injectable glucocorticoids within 1 month before surgery
- Current pregnancy
- Unable to undergo the multimodal pain protocol due to comorbidities or allergies to study medications
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Saint Louis University
St Louis, Missouri, United States, 63110
Actively Recruiting
Research Team
S
Scott Kaar
CONTACT
A
Allison Gruender
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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