Evaluating a Modified Olfactory Training Device for Adults With Post-Viral Loss of Smell

What this Trial Is About

Researchers are evaluating the effectiveness of a modified olfactory training device for treating patients with post-viral olfactory dysfunction. This trial aims to compare how well the modified device works versus the traditional olfactory training device. The study will use various measures to assess changes in smell function and brain-related changes over time to better understand how olfactory training helps these patients. Participants are divided into three groups one group uses the conventional olfactory training device with active odors, another uses a placebo device with odorless solution, and the third uses the modified olfactory training device designed to improve odor delivery through bidirectional airflow and pressure. Training involves smelling four specific odors twice daily for 5 minutes each session over 12 weeks. Each odor is sniffed in a structured sequence with rest intervals. During the study, participants will be assessed at baseline and at multiple follow-up points up to 24 months. Tests include the Sniffin Sticks test to measure smell ability, MRI scans to evaluate brain and olfactory bulb changes, nerve-related potentials, and questionnaires about smell disorders. Researchers will also monitor training adherence and safety. After completing the study, participants will be informed about their group and offered the option to continue odor training.

The Efficacy of Modified Olfactory Training Method for Patients With Post-viral Olfactory Dysfunction