Actively Recruiting
Efficacy of N-acetylcysteine in Preventing Radiotherapy-Induced Oral Mucositis in Head and Neck Cancer Patients.
Led by Mansoura University · Updated on 2025-01-15
50
Participants Needed
1
Research Sites
47 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
A prospective, randomized, controlled, parallel clinical trial will be conducted at Clinical Oncology and Nuclear Medicine Center at Mansoura University Hospital to assess the efficacy of N-acetylcysteine in the prevention of radiotherapy induced oral mucositis in Head and Neck cancer patients.
CONDITIONS
Official Title
Efficacy of N-acetylcysteine in Preventing Radiotherapy-Induced Oral Mucositis in Head and Neck Cancer Patients.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults over 18 years diagnosed with squamous cell carcinoma of the head and neck scheduled for curative radiotherapy of at least 50 Gy, with or without chemotherapy
- Healthy oral mucosa at the start of the study
- Adequate bone marrow function: Hemoglobin 10 g/dL, platelet count 75 103/microliter, and absolute neutrophil count 1.5 103/microliter
- ECOG performance status 2 or better
You will not qualify if you...
- History of chemotherapy or radiotherapy treatments
- Signs of systemic infections
- Pregnant or lactating women
- Current use of systemic analgesics
- Liver disorders or renal failure with eGFR less than 30 ml/min/1.73m2
- Inability to follow instructions or complete questionnaires
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Clinical Oncology and Nuclear Medicine of Mansoura University Hospital
Al Mansurah, Egypt
Actively Recruiting
Research Team
R
Reem Abou-Elezz, BSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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