Comparing Oral Contraceptives, Progesterone, and Inositol for Menstrual Cycle Regulation in Women with Polycystic Ovary Syndrome

What this Trial Is About

Researchers are evaluating the effectiveness of oral contraceptives, oral progesterone didrogesterone, and myo-inositol in regulating menstrual cycles among women diagnosed with polycystic ovary syndrome PCOS. PCOS is a common hormonal disorder in reproductive-aged women associated with menstrual irregularities, excess male hormones, and polycystic ovaries. The study aims to compare these treatments to find alternatives to oral contraceptives, especially for women who cannot use them due to health risks or who want to preserve fertility. The study includes 150 women aged 15 to 40 years with PCOS diagnosed by accepted criteria. Participants are randomly assigned to one of three groups oral contraceptive users taking a combined pill daily for 21 days with a 7-day break per cycle, oral progesterone didrogesterone users taking 10 mg twice daily from days 15 to 25 of each cycle, or inositol users taking 2 g daily. All treatments last for 6 months. The oral contraceptive group serves as the standard treatment comparison. Participants will have clinical assessments at the start and after 6 months, including menstrual regularity, ovarian ultrasound to check morphology, hormone levels, and signs of excess male hormones such as hirsutism and acne. Researchers will track how well menstrual cycles are restored and evaluate changes in ovarian appearance and hormone symptoms. Patient satisfaction and treatment tolerability will also be recorded. The study lasts 6 months with regular follow-up visits to monitor outcomes and safety.

Efficacy of Oral Contraceptive, Progesterone, and Inositol on Menstrual Regulation in PCOS