Actively Recruiting
Efficacy of Organoid-Based Drug Screening to Guide Treatment for Locally Advanced Thyroid Cancer
Led by West China Hospital · Updated on 2024-12-05
75
Participants Needed
1
Research Sites
234 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The current study aims to explore the potential advantages of anti-cancer therapy that is implemented based on drug sensitivity testing. This pertains to individuals with locally advanced thyroid cancer who have undergone conventional therapy in the past or unresectable patients .
CONDITIONS
Official Title
Efficacy of Organoid-Based Drug Screening to Guide Treatment for Locally Advanced Thyroid Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult participants initially diagnosed with locally advanced thyroid cancer or with persistent or recurrent thyroid cancer, including cervical nodal recurrence
- Diagnosis includes papillary, follicular, medullary, poorly differentiated, or anaplastic thyroid carcinoma
- Evidence of tumor extension beyond the thyroid or locally invasive disease considered at risk for incomplete surgical removal
- At least one measurable tumor lesion according to modified response criteria
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2
- Normal organ and bone marrow function
- Adequate organ function including bone marrow, coagulation, kidney, liver, and heart within 28 days before registration
- Ability to swallow pills
- Signed informed consent form
- Expected survival time longer than 2 months
You will not qualify if you...
- Contraindications to the targeted drugs used in organoid drug sensitivity tests
- Incomplete clinical data
- Severe organ dysfunction, metabolic diseases, or other conditions greatly affecting survival
- Other active malignant diseases requiring treatment
- Pregnancy or breastfeeding
- Absence of target tumor lesions
- Deemed unsuitable for inclusion by the researchers
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
West China hospital
Chengdu, Sichuan, China, 610041
Actively Recruiting
Research Team
Z
Zhihui Li, Professor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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