Actively Recruiting
Efficacy of Personalized Repetitive Transcranial Magnetic Stimulation Protocol Based on Functional Reserve to Enhance Upper Limb Function in Subacute Stroke Patients
Led by Samsung Medical Center · Updated on 2026-04-24
120
Participants Needed
1
Research Sites
137 weeks
Total Duration
On this page
Sponsors
S
Samsung Medical Center
Lead Sponsor
N
National Research Foundation of Korea
Collaborating Sponsor
AI-Summary
What this Trial Is About
The objective of this study was to determine the effects of protocols of repetitive transcranial magnetic stimulation (rTMS) therapy based on the functional reserve of each hemiplegic stroke patient in subacute phase, compared to conventional low-frequency rTMS therapy on contralateral M1. Investigators hypothesized that the functional reserve of each hemiplegic stroke patient will be different, and therefore an appropriate simulating target for rTMS therapy is needed. In addition, this approach could be more effective compared to conventional protocols applied to stroke patients regardless of their severity, predicted mechanism of motor function recovery, or functional reserves.
CONDITIONS
Official Title
Efficacy of Personalized Repetitive Transcranial Magnetic Stimulation Protocol Based on Functional Reserve to Enhance Upper Limb Function in Subacute Stroke Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Hemiplegic stroke patients in the subacute phase (7 days to 3 months from onset) who are currently hospitalized
- Fugl-Meyer Assessment score of the upper extremity 42 or below
- Adequate language and cognitive function to perform at least a 1-step obey-command
- Pre-stroke functional level of modified Rankin Scale 1 or less
- Aged 19 years or older
- Patients willing to sign the informed consent
You will not qualify if you...
- Contraindications to rTMS, such as epilepsy, implanted metal objects in the head, or history of craniotomy
- Progressive or hemodynamically unstable medical conditions
- Coexisting neurological conditions like spinal cord injury or Parkinson's disease
- Major psychiatric disorders such as major depression, schizophrenia, or dementia
- Contraindications to MRI studies
- Pregnancy or lactation
- Patients who have refused to participate in this study
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Samsung Medical Center
Seoul, South Korea, 06351
Actively Recruiting
Research Team
W
Won Hyuk Chang, PhD
CONTACT
H
Ho Seok Lee, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
6
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